Circulating non-coding RNAs as non-invasive diagnostic markers of endometriosis: a comprehensive meta-analysis

  • Yanhui Li
  • Qionghua ChenEmail author



Circulating non-coding RNAs have great potential for diagnosing endometriosis as non-invasive markers. We have assessed the potential accuracy and utility for diagnosis of endometriosis.


We searched many bases to identify the included literature, which included English bases, such as, Pubmed, Embase, Web of Science, Cochrane library and Chinese bases, for instance, CNKI, Wang Fang, VIP, DuXiu, ChaoXing. We also calculated the general sensitivity and specificity, negative likelihood ratio, positive likelihood ratio, diagnostic odds ratio, ROC curve plotting and so on with Stata 15. I2 could test the heterogeneity of the meta-analysis, the funnel plot valuated whether meta-analysis had a publication bias. Regression analysis could explore heterogeneity in studies.


Comprehensive reading and integrating extracted data, we included 11 published papers. The total number of people included in the case group was 453, and the control group was 362. We, respectively, calculated the general sensitivity and general specificity which were 0.81 (95% CI 0.76–0.85) and 0.77 (95% CI 0.71–0.82) by bivariate analysis. The area under the ROC curve was 0.86 (95% CI 0.83–0.89). There was significant heterogeneity in studies which is I2 = 89.62% (95% CI 87.41%–91.83%). In addition, the results of meta-regression and subgroup analysis showed that the heterogeneity might come from gold standard, evaluation standard, experimental group size, experimental sample and race


The circulating non-coding RNAs have great ability of diagnosing endometriosis as non-invasive markers which were performed robustly and accurately.


Non-coding RNAs Endometriosis Biomarkers Non-invasive and meta 



We sincerely thank Professor Chen Qionghua for his technical support. The study was supported by grant 81871145 of National Natural Science Foundation of China. At the same time, for earlier versions of this manuscript, we are grateful for many helpful comments from each anonymous reviewer.

Compliance with ethical standards

Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval

The authors declare that there are no ethical issues, because this meta-analysis required the study of previous studies without any intervention of the patients.

Supplementary material

404_2019_5290_MOESM1_ESM.docx (43 kb)
Supplementary material 1 (docx 43 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of First Affiliated Hospital of Xiamen UniversityXiamenChina
  2. 2.Department of Xiamen UniversityXiamenChina

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