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Overweight and obesity do not determine worst prognosis in endometrioid endometrial carcinoma

  • Gabriela Villaça Chaves
  • Tatiana de Almeida Simao
  • Luis Felipe Ribeiro Pinto
  • Miguel Angelo Martins Moreira
  • Anke Bergmann
  • Claudia Bessa Pereira ChavesEmail author
Gynecologic Oncology
  • 69 Downloads

Abstract

Purpose

The aim of this study was to investigate the impact of body mass index (BMI) on disease-free survival (DFS) and overall survival (OS) in women diagnosed with EEC and treated at the Brazilian National Cancer Institute.

Methods

The study comprised 849 women diagnosed with EEC who underwent surgical treatment between January, 2000 and December, 2011. The demographic and clinical characteristics of these patients were collected from medical records and their nutritional status was based on the BMI criteria. Univariate (OS and DFS) and multivariate analyses were performed using the Kaplan–Meier method and Cox proportional hazards models, respectively.

Results

About 83.2% of patients were obese or overweight at time of diagnosis, with a mean BMI of 31.83. Patients were followed for an average of 34.97 months. There were 111 recurrences (13.1%) and 140 deaths (16.5%), with mean DFS of 51.90 months and mean OS of 52.25 months. There was no significant association between BMI and DFS or OS. In multivariate analysis we did not find an increased hazard of recurrence or death among overweight or obese patients.

Conclusion

Overweight and obesity had no impact on EEC prognosis on the assessed cohort. Further studies are warranted.

Keywords

Endometrial cancer Obesity Survival Body mass index 

Notes

Author contributions

GV Chaves: data analysis, manuscript writing/editing. TA Simão: data collection, manuscript writing/editing. LFR Pinto: protocol/project development, manuscript writing/editing. MAM Moreira: data collection, manuscript writing/editing. A Bergman: data analysis, manuscript writing/editing. CBP Chaves: protocol/project development, data collection and management, manuscript writing/editing.

Funding

This work was supported by Ministry of Health (Brazil), Conselho Nacional Para Desenvolvimento Científico e Tecnológico (CNPq-Brazil).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

404_2019_5281_MOESM1_ESM.docx (31 kb)
Supplementary file1  (DOCX 31 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Gabriela Villaça Chaves
    • 1
  • Tatiana de Almeida Simao
    • 2
  • Luis Felipe Ribeiro Pinto
    • 6
  • Miguel Angelo Martins Moreira
    • 4
  • Anke Bergmann
    • 3
  • Claudia Bessa Pereira Chaves
    • 3
    • 5
    Email author
  1. 1.Nutrition DepartmentCancer Hospital II, Brazilian National Cancer InstituteRio de JaneiroBrazil
  2. 2.Biochemistry DepartmentState University of Rio de JaneiroRio de JaneiroBrazil
  3. 3.Clinical Research DivisionRio de JaneiroBrazil
  4. 4.Genetics ProgramBrazilian National Cancer InstituteRio de JaneiroBrazil
  5. 5.Gynecologic Oncology DepartmentCancer Hospital II, Brazilian National Cancer InstituteRio de JaneiroBrazil
  6. 6.Molecular Carcinogenesis ProgramBrazilian National Cancer InstituteRio de JaneiroBrazil

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