Overweight and obesity do not determine worst prognosis in endometrioid endometrial carcinoma
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The aim of this study was to investigate the impact of body mass index (BMI) on disease-free survival (DFS) and overall survival (OS) in women diagnosed with EEC and treated at the Brazilian National Cancer Institute.
The study comprised 849 women diagnosed with EEC who underwent surgical treatment between January, 2000 and December, 2011. The demographic and clinical characteristics of these patients were collected from medical records and their nutritional status was based on the BMI criteria. Univariate (OS and DFS) and multivariate analyses were performed using the Kaplan–Meier method and Cox proportional hazards models, respectively.
About 83.2% of patients were obese or overweight at time of diagnosis, with a mean BMI of 31.83. Patients were followed for an average of 34.97 months. There were 111 recurrences (13.1%) and 140 deaths (16.5%), with mean DFS of 51.90 months and mean OS of 52.25 months. There was no significant association between BMI and DFS or OS. In multivariate analysis we did not find an increased hazard of recurrence or death among overweight or obese patients.
Overweight and obesity had no impact on EEC prognosis on the assessed cohort. Further studies are warranted.
KeywordsEndometrial cancer Obesity Survival Body mass index
GV Chaves: data analysis, manuscript writing/editing. TA Simão: data collection, manuscript writing/editing. LFR Pinto: protocol/project development, manuscript writing/editing. MAM Moreira: data collection, manuscript writing/editing. A Bergman: data analysis, manuscript writing/editing. CBP Chaves: protocol/project development, data collection and management, manuscript writing/editing.
This work was supported by Ministry of Health (Brazil), Conselho Nacional Para Desenvolvimento Científico e Tecnológico (CNPq-Brazil).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Global and Regional Estimates of the Incidence and Mortality for 38 Cancers: GLOBOCAN (2018) Lyon: International Agency for Research on Cancer/World Health OrganizationGoogle Scholar
- 2.Instituto Nacional de Cancer José Alencar Gomes da Silva 2018 INCA—Instituto Nacional de Câncer—Estimativa 2018 Ministério da Saúde Instituto Nacional de Cancer José Alencar Gomes da Silva 978-85-7318-283-5Google Scholar
- 5.World Cancer Research Fund and American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Institute for Cancer Research, WashingtonGoogle Scholar
- 16.World Health Organization (2000) Obesity: preventing and managing the global epidemic: Report of a WHO ConsultationGoogle Scholar
- 26.Temkin SM, Pezzullo JC, Hellmann M et al (2007) Is body mass index an independent risk factor of survival among patients with endometrial cancer? Am J Clin Oncol 30:8–14. https://doi.org/10.1097/01.coc.0000236047.42283.b8 CrossRefPubMedGoogle Scholar
- 27.Mauland KK, Trovik J, Wik E et al (2011) High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer. Br J Cancer 104:921–926. https://doi.org/10.1038/bjc.2011.46 CrossRefPubMedPubMedCentralGoogle Scholar
- 32.World Cancer Research Fund/American Institute for Cancer Research (2018) Diet, nutrition, physical activity and cancer: a global perspective. American Institute for Cancer Research, WashingtonGoogle Scholar