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Archives of Gynecology and Obstetrics

, Volume 299, Issue 6, pp 1567–1577 | Cite as

Calprotectin in pregnancy and pregnancy-associated diseases: a systematic review and prospective cohort study

  • Günther A. Rezniczek
  • Claudia Förster
  • Ziad Hilal
  • Timm Westhoff
  • Clemens B. TempferEmail author
Maternal-Fetal Medicine
  • 59 Downloads

Abstract

Purpose

Calprotectin, a marker of acute and chronic inflammation, may play a role in pregnancy-associated disorders. We aimed to summarize available clinical data on calprotectin in pregnancy and to establish normal values of calprotectin during the course of pregnancy.

Methods

We performed a systematic review of the databases PubMed and Cochrane Central Register of Controlled Trials to identify experimental and clinical evidence assessing the role of calprotectin in pregnancy. In addition, we performed a prospective cohort study assessing serum and urine calprotectin throughout pregnancy.

Results

We identified 17 studies investigating 1638 pregnant women, 151 newborns, and 99 non-pregnant controls, measuring calprotectin in different compartments. Calprotectin was present in meconium and elevated in fecal samples of pregnant women with active inflammatory bowel disease. In women with pregnancy-induced hypertension, mild and severe preeclampsia (PE), calprotectin was significantly elevated in maternal plasma and serum, but not in fetal serum, amniotic fluid, and umbilical cord blood. For the cohort study, we recruited 196 pregnant women. PE and concomitant renal disease were present in 6/196 (3%) and 11/196 (5.6%) of women, respectively. Throughout pregnancy, median serum and urine levels of calprotectin largely exceed reported concentrations of the healthy non-pregnant population, but showed no significant variations between trimesters 1–3 and post-partum. Calprotectin in serum was correlated with systolic blood pressure and in urine with leukocytes and total protein. No significant differences were found in subgroup analyses of smokers vs. non-smokers, PE vs. none, and renal disease (kidney stones, reflux) vs. none.

Conclusion

Calprotectin concentrations in amnion fluid and stools serve as potential indicators of inflammatory states during pregnancy. Urinary calprotectin concentrations are continuously high during pregnancy and show no significant variations between trimesters 1–3 and post-partum.

Keywords

Calprotectin Pregnancy Renal disease Preeclampsia 

Abbreviations

AF

Amniotic fluid

CAL

Calprotectin

CCS

Case–control study

CR

Case report

CS

Cesarean section

ELISA

Enzyme-linked immunosorbent assay

IBD

Inflammatory bowel disease

IFN

Interferon

IL

Interleukin

IUGR

Intrauterine growth restriction

PAHD

Pregnancy-associated hypertensive disorder

PCCS

Prospective case–control study

PCOS

Prospective cohort study

PCS

Prospective case series

PE

Preeclampsia

PIH

Pregnancy-induced hypertension

PROM

Premature rupture of membranes

RCT

Randomized controlled trial

SID

Systemic inflammatory disease

Notes

Acknowledgements

The study was funded by the German Research Foundation (Research Unit FOR1368).

Author contributions

TW designed the study, CF collected the material, GR, ZH, and CT analyzed the data and wrote the manuscript. All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Ruhr-Universität Bochum Ethics Committee. Written informed consent was obtained from all patients described in the prospective cohort study.

Data availability

The data sets used and analyzed during the current study are available from the corresponding author on reasonable request.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyRuhr-Universität Bochum – Marien Hospital HerneHerneGermany
  2. 2.Department of Internal Medicine and NephrologyRuhr-Universität BochumBochumGermany

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