Archives of Gynecology and Obstetrics

, Volume 299, Issue 5, pp 1399–1404 | Cite as

Compare two different usages of FRD for detecting high-grade cervical lesions and invasive cancer

  • Yuping Dai
  • Lirong Wang
  • Donghong LiEmail author
Gynecologic Oncology



To evaluate two usages of the folate receptor-mediated staining solution (FRD) for detecting high-grade cervical lesions and invasive cancer, and compared with cytology test (TCT) and human papillomavirus (HPV) testing.


FRD sampling and FRD direct staining methods were used for detecting high-grade cervical lesions and invasive cancer. As a comparison, TCT and HPV testing were also applied for screening high-grade cervical lesions and invasive cancer. The sensitivity and specificity of TCT, HPV testing, and staining results of FRD were analyzed by the SPSS software.


In this study, 317 patients with biopsy were collected. The positive rate of FRD sampling method was 35.33% (112/317), and positive rate of FRD direct staining was 48.90% (155/317). Area under the curve (AUC) of TCT, HPV testing, FRD sampling and FRD direct staining were 0.53, 0.55, 0.58, and 0.75, respectively. The sensitivity of TCT, HPV, FRD sampling and FRD direct staining was 69.72%, 97.25%, 64.22% and 81.65%, respectively, and the specificity was 37.98%, 12.98%, 79.81% and 68.27%, respectively.


Compared with TCT and HPV testing, two usages of FRD methods have compatible sensitivity and high specificity to detect high-grade cervical lesions and invasive cancer. FRD direct staining may be comfortable for routine cervical cancer screening


Folate receptor-mediated staining solution (FRD) High-grade cervical lesions Invasive cancer Cytology test Human papillomavirus testing 


Author contributions

DHL: guarantor of integrity of the entire study, study concepts and design, definition of intellectual content, literature research, statistical data analysis, manuscript preparation, editing, and review. YPD: clinical studies and studies. LRW: clinical studies and data acquisition.


This study was not funded.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, Affiliated Guangren Hospital, School of MedicineXi’an Jiaotong UniversityXi’anChina
  2. 2.Department of Gynecology Oncology, The Affiliated Shaanxi Provincial Cancer Hospital, School of MedicineXi’an Jiaotong UniversityXi’anChina

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