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Archives of Gynecology and Obstetrics

, Volume 299, Issue 1, pp 1–5 | Cite as

What is the evidence for lymphadenectomy in presumed early ovarian cancer?

  • Barbara SchmalfeldtEmail author
  • Christine Brambs
  • Alexander Burges
  • Ahmed El-Balat
  • Günter Emons
  • Daniel Fink
  • Christina Fotopoulou
  • Martina Gropp-Meier
  • Lars-Christian Hanker
  • Philipp Harter
  • Annette Hasenburg
  • Steffen Hauptmann
  • Felix Hilpert
  • Rainer Kimmig
  • Stefan Kommoss
  • Christian Kurzeder
  • Sven Mahner
  • Frederik Marmé
  • Doris Mayr
  • Werner Meier
  • Ivo Meinhold-Heerlein
  • Alexander Mustea
  • Olaf Ortmann
  • Gülten Oskay-Özcelik
  • Jacobus Pfisterer
  • Martin Pölcher
  • Ingo B. Runnebaum
  • Willibald Schröder
  • Berno Tanner
  • Uwe Wagner
  • Pauline Wimberger
  • Jalid Sehouli
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Introduction

In 2017 the results of the LION phase III prospective randomised trial (LION: lymphadenectomy in ovarian neoplasms—a prospective randomized AGO study group led gynaecologic cancer intergroup trial), investigating the value of systematic lymph node dissection (LND) in advanced ovarian cancer, were published, demonstrating no progression free or overall survival benefit for systematic lymphadenectomy in advanced (≥ IIB) patients with complete tumour clearance and macroscopically normally appearing lymph nodes. Primary endpoint of the study was overall survival. Secondary endpoints were morbidity and perioperative mortality. These data were a game changer in establishing the optimal management standards of advanced disease and has significant implications in national and international guidelines.

The special and novel aspect of the LION study was that all participating centres had to demonstrate for their eligibility a high standard surgical quality and expertise via the...

Keywords

Early ovarian cancer Lymphadenectomy Surgical staging Survival 

Notes

Author contributions

B. Schmalfeldt, data analysis, manuscript writing, editing. Brambs C, manuscript review. Burges A, manuscript review. El-Balat A, manuscript review. Emons G, manuscript review. Fink D, manuscript review. Fotopoulou C, manuscript writing, manuscript review. Gropp-Meier M, manuscript review. Hanker L-C, manuscript review. Harter P, manuscript review. Hasenburg A, manuscript review. Hauptmann S, manuscript review. Hilpert F, manuscript review. Kimmig R, manuscript review. Kommoss S, manuscript review. Kurzeder C, manuscript review. Mahner S, manuscript review. Marmé F, manuscript review. Mayr D, manuscript review. Meier W, manuscript review. Meinhold-Heerlein I, manuscript review. Mustea A, manuscript review. Ortmann O, manuscript review. Oskay-Özcelik G, manuscript review. Pfisterer J, manuscript review. Pölcher M, manuscript review. Runnebaum IB, manuscript review. Schröder W, manuscript review. Tanner B, manuscript review. Wagner U, manuscript review. Wimberger P, manuscript review. Sehouli J manuscript review. For the Kommission Ovar of the AGO (Working Group Gynecologic Oncology).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Barbara Schmalfeldt
    • 1
    Email author return OK on get
  • Christine Brambs
    • 2
  • Alexander Burges
    • 3
  • Ahmed El-Balat
    • 4
  • Günter Emons
    • 5
  • Daniel Fink
    • 6
  • Christina Fotopoulou
    • 7
  • Martina Gropp-Meier
    • 8
  • Lars-Christian Hanker
    • 9
  • Philipp Harter
    • 10
  • Annette Hasenburg
    • 11
  • Steffen Hauptmann
    • 12
  • Felix Hilpert
    • 13
  • Rainer Kimmig
    • 14
  • Stefan Kommoss
    • 15
  • Christian Kurzeder
    • 16
  • Sven Mahner
    • 17
  • Frederik Marmé
    • 18
  • Doris Mayr
    • 19
  • Werner Meier
    • 20
  • Ivo Meinhold-Heerlein
    • 21
  • Alexander Mustea
    • 22
  • Olaf Ortmann
    • 23
  • Gülten Oskay-Özcelik
    • 24
  • Jacobus Pfisterer
    • 25
  • Martin Pölcher
    • 26
  • Ingo B. Runnebaum
    • 27
  • Willibald Schröder
    • 28
  • Berno Tanner
    • 29
  • Uwe Wagner
    • 30
  • Pauline Wimberger
    • 31
  • Jalid Sehouli
    • 32
  1. 1.Department of GynecologyUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Department of Gynecology and ObstetricsTechnical University of MunichMunichGermany
  3. 3.Department of Obstetrics and Gynecology, University HospitalLMU MunichMunichGermany
  4. 4.Department of Obstetrics and GynecologyGoethe University FrankfurtFrankfurtGermany
  5. 5.Department of Obstetrics and GynecologyUniversity Medicine GoettingenGoettingenGermany
  6. 6.Department of Gynecology and Breast Cancer CenterUniversity Hospital ZurichZurichSwitzerland
  7. 7.West London Gynaecological Cancer Centre and Ovarian Cancer Action Research CentreImperial College Healthcare Trust LondonLondonUK
  8. 8.Department of Obstetrics and GynecologyOberschwabenklinik Hospital St. Elisabeth RavensburgRavensburgGermany
  9. 9.Department of Obstetrics and GynecologyUniversity-Hospital Schleswig-HolsteinRavensburgGermany
  10. 10.Department of GynecologyKliniken Essen MitteEssenGermany
  11. 11.Department of Obstetrics and Gynecology, Mainz Medical SchoolUniversity of MainzMainzGermany
  12. 12.Maastricht University Medical CentreMaastrichtThe Netherlands
  13. 13.Breast Center at the Jerusalem HospitalHamburgGermany
  14. 14.Department of Gynaecology and ObstetricsUniversity of Duisburg-EssenEssenGermany
  15. 15.Department of Women’s HealthTübingen University HospitalTübingenGermany
  16. 16.Women’s Clinic and Gynecological Oncology, University Hospital BaselUniversity of BaselBaselSwitzerland
  17. 17.Department of Obstetrics and Gynecology, University HospitalLudwig-Maximilians-University MunichMunichGermany
  18. 18.Department of Obstetrics and GynecologyUniversity Hospital HeidelbergHeidelbergGermany
  19. 19.Department of PathologyLudwig-Maximilians-UniversityMunichGermany
  20. 20.Department of Gynecology and ObstetricsUniversity HospitalDuesseldorfGermany
  21. 21.Department of Gynecology and Obstetrics, University Hospital GiessenJustus-Liebig-University GiessenGiessenGermany
  22. 22.Department of Gynaecology and ObstetricsUniversity Medicine of GreifswaldGreifswaldGermany
  23. 23.Department of Obstetrics and GynecologyUniversity Medical CenterRegensburgGermany
  24. 24.Private Practice for Gynecologic OncologyBerlinGermany
  25. 25.Gynecologic Oncology CenterKielGermany
  26. 26.Department of GynecologyRed Cross HospitalMunichGermany
  27. 27.Department of Gynecology and Reproductive Medicine, University Women’s Hospital JenaJena University HospitalJenaGermany
  28. 28.Department of Gynecologic Oncology and GynecologyGynaekologicum BremenBremenGermany
  29. 29.Private Practice for Obstetrics and GynecologyHohen NeuendorfGermany
  30. 30.Dept. Gyn. Endocrinology and Reproductive MedicineUniversity Hospital Giessen and MarburgGiessenGermany
  31. 31.Department of GynecologyTechnical University DresdenDresdenGermany
  32. 32.Department of GynecologyCharité Medical University of BerlinBerlinGermany

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