Is there a role for HIPEC in ovarian cancer?
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Hyperthermic intraperitoneal chemotherapy (HIPEC) is promoted by some as a standard treatment for peritoneal carcinomatosis of epithelial ovarian cancer (EOC) and other tumor entities, despite lack of robust data supporting this. Publicly available evidence addressing the value of HIPEC in EOC is rather inconclusive, revealing contradictory and inconsistent results while some studies even report harm to the patients from a higher morbidity. On this ground, we cannot recommend the implementation and use of HIPEC outside of a randomized clinical trial setting.
KeywordsHIPEC Ovarian cancer Cytoreductive surgery Randomized trials
Protocol/project development: Harter, Fotopoulou. Data collection or management: all authors. Data analysis: all authors. Manuscript writing/editing: all authors.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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