Galectin-3 as a novel biomarker in women with PCOS
This study aimed at evaluating galectin-3 levels as a novel metabolic biomarker in women with PCOS.
Ninety consecutive women with PCOS fulfilling the inclusion criteria were divided into two groups according to the presence of metabolic syndrome as MetS+ and MetS−. Clinical, hormonal, and metabolic parameters and galectin-3 levels were compared between the groups. Correlation analyses were performed between galectin-3 and clinical and metabolic parameters.
Ninety PCOS subjects were enrolled in the study, 25 of which were diagnosed with MetS. Waist-to-hip ratio, systolic and diastolic blood pressures, triglyceride, HOMA-IR, FAI, FGS, and galectin-3 levels were significantly higher in the MetS+ group compared with the MetS− group (13.19 ± 5.63 vs 9.37 ± 3.99 ng/mL, respectively, p = 0.001). HDL cholesterol was significantly higher in the MetS− group than in the MetS+ one. Galectin-3 levels were found to be positively correlated with systolic blood pressure (r = 0.450, p < 0.01), diastolic blood pressure (r = 0.293, p < 0.01), and triglyceride levels (r = 0.218, p < 0.05) in women with PCOS.
Galectin-3 may be a promising novel biomarker in women with PCOS. Galectin-3 levels were significantly higher in the MetS+ group compared with the MetS− one and positively correlated with systolic, diastolic blood pressures and triglyceride levels in women with PCOS.
KeywordsPolycystic ovary syndrome Galectin-3 Metabolic syndrome Metabolic biomarker Cardiometabolic risk
We declare that we have no conflict of interest.
GAI: Methodology, data collection, data analysis, writing and editing the manuscript; CK: Data collection; GA: Data collection; BY: editing the manuscript; TP: editing the manuscript.
Compliance with ethical standards
The study protocol was approved by the Ethics Committee of the Marmara University.
Conflict of interest
The authors declare that they have no conflict of interest and funding was not received for performing the study.
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