Archives of Gynecology and Obstetrics

, Volume 298, Issue 4, pp 685–688 | Cite as

An effect of maternal nifedipine therapy on fetoplacental blood flow: a prospective study

  • Ahmet NamazovEmail author
  • Leonti Grin
  • Resul Karakus
  • Mehmet Uludogan
  • Habibe Ayvaci
Maternal-Fetal Medicine



The aim of this study is to assess the effects of maternal nifedipine administration on placental and fetal blood flow.


A total of 29 patients with preterm labor diagnosis admitted to the tertiary care center, Zeynep Kamil Hospital, were evaluated. Before and 24–48 h after administration of oral nifedipine, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery, ductus venosus, umbilical artery, and maternal uterine artery blood flow.


After 24 and 48 h of therapy, there were no changes in mean PI and RI in the umbilical arteries and ductus venosus (p > 0.05). Fetal middle cerebral artery and maternal uterine artery PI and RI values showed a significant reduction 24–48 h after oral nifedipine therapy (p < 0.05).


Our study showed that 24 and 48 h after oral nifedipine therapy, there is a significant increase in fetal MCA and maternal uterine artery blood flow, while fetal umbilical artery and ductus venosus Doppler values do not change.


Nifedipine Umbilical artery Middle cerebral artery Ductus venosus Uterine artery 


Author contributions

AN: manuscript writing–editing, data analyzing, project administration. LG: manuscript editing. RK: data collection. MU: data analyzing. HA: supervisor, data analyzing.

Compliance with ethical standards

Conflict of interest

We have no potential conflict of interest to declare.

Informed consent

All pregnant women gave their informed written consent to participate in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, Barzilai University Medical CenterBen-Gurion University of Negev, Faculty of Health SciencesAshkelonIsrael
  2. 2.Obstetrics and Gynecology DepartmentZeynep Kamil HospitalIstanbulTurkey

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