Archives of Gynecology and Obstetrics

, Volume 298, Issue 3, pp 477–485 | Cite as

Do probiotics effectively ameliorate glycemic control during gestational diabetes? A systematic review

  • Suelen Dallanora
  • Yasmin Medeiros de Souza
  • Rúbia Garcia Deon
  • Clare A. Tracey
  • Ana Amélia Freitas-Vilela
  • Luiz Fernando Wurdig Roesch
  • Roberta Hack MendesEmail author



Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. The aim of this work was to systematically review all studies in which probiotic supplements were used during pregnancy and analyse the effects on GDM.


The data were collected using the medical subheading (MeSH) terms: (“diabetes, gestational”[MeSH Terms] OR (“diabetes”[All Fields] AND “gestational”[All Fields]) OR “gestational diabetes”[All Fields] OR (“gestational”[All Fields] AND “diabetes”[All Fields])) AND (“probiotics”[MeSH Terms] OR “probiotics”[All Fields]). The search included original articles written in English/Portuguese and published between 2012 and 2017.


Of the 31 articles identified, seven met the inclusion criteria and were included in this review. In these studies, the sample size ranged from 60 to 373 women with GDM, which was between 24 and 40 weeks of pregnancy (second and third trimesters). Results demonstrated that probiotics used during pregnancy in women with GDM may improve glycaemic control and reduce VDL cholesterol, triglycerides, and inflammatory markers.


The present systematic review highlights the importance of probiotics for glycemic control and decrease of inflammatory markers in GDM. Further long-term studies should be conducted to elucidate this interaction.


Gestational diabetes Gut microbiome Lactobacillus Bifidobacterium 


Author contributions

SD: Lead, the author worked on the conceptualization of the idea, search of the articles, data extraction and writing of original draft, review and editing. of manuscript. YM: the author worked on the search of articles, data extraction and support on the writing of original draft of manuscript. RGD: the author supported on the project administration and writing of original draft, review and editing of manuscript. CAT: the author supported on the writing of the original draft, review and editing. LR: the author supported on the conceptualization of the idea, writing of original draft, review and editing of the manuscript. AFV: the author supported on the project administration and writing of original draft, review and editing of the manuscript. RHM: the author worked on the conceptualization of the idea, project administration, methodology, writing of original draft, review and editing of the manuscript.

Compliance with ethical standards

Conflict of interest

No support  was received from any organization for the submitted work. S.D., Y.M., R.G.D., A.A.F.V., L.F.R. and R.H.M. declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Suelen Dallanora
    • 1
    • 2
  • Yasmin Medeiros de Souza
    • 1
  • Rúbia Garcia Deon
    • 1
  • Clare A. Tracey
    • 5
    • 6
  • Ana Amélia Freitas-Vilela
    • 3
  • Luiz Fernando Wurdig Roesch
    • 4
  • Roberta Hack Mendes
    • 1
    • 5
    Email author
  1. 1.Universidade Regional Integrada do Alto Uruguai e das Missões-URIFrederico WestphalenBrazil
  2. 2.Instituto de Cardiologia do Rio Grande do SulPorto AlegreBrazil
  3. 3.Unidade Acadêmica Especial de Ciências da Saúde, Curso de Medicina, Universidade Federal de Goiás/Regional JataíJataíBrazil
  4. 4.Universidade Federal do PampaSão GabrielBrazil
  5. 5.University College Dublin, Science Centre SouthDublinIreland
  6. 6.Maastricht UniversityMaastrichtThe Netherlands

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