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Does tumor grade influence the rate of lymph node metastasis in apparent early stage ovarian cancer?

  • Gynecologic Oncology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the prevalence of regional lymph node (LN) metastasis in patients with non-clear cell epithelial ovarian cancer apparently confined to the ovary, stratified by tumor grade.

Methods

The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database was accessed (1988–2014). We identified patients with epithelial ovarian carcinoma of serous, endometrioid and mucinous histology apparently confined to the ovary who underwent extensive lymphadenectomy (defined as at least 20 lymph nodes removed). Demographics, tumor histology, grade and lymph node status were collected. Comparisons were made with Chi square and Mann–Whitney U tests.

Results

A total of 1242 women met the inclusion criteria. Endometrioid adenocarcinoma was the most common histology (564 patients (45.4%)) while 443 (35.7%) and 235 (18.9%) patients had serous, and mucinous adenocarcinoma, respectively. The rate of LN metastasis in low-grade serous was 9.0% (6/67) vs. 14.4% (54/376) in high-grade serous histology (OR, 1.71, 95% CI 0.70, 4.14, p = 0.24). In patients with low-grade endometrioid tumors, the rate of LN metastasis was 1.7% (7/407) vs. 5.1% (8/157) observed in those with high-grade tumors (OR: 3.07, 95% CI 1.09, 8.61, p = 0.033). Lastly, the rate of LN metastasis in mucinous histology was 1.7% (3/177) in low-grade vs. 8.6% (5/58) in high-grade tumors (OR: 5.47, 95% CI 1.27, 23.66, p = 0.024).

Conclusions

Regional LN metastasis in apparent stage I low-grade mucinous and endometrioid ovarian tumors is infrequent.

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Funding

The authors declare no source of funding for the research conducted.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Helen O’Dickens Women’s Health Center, 3400 Spruce Street, Philadelphia, PA, USA

    Dimitrios Nasioudis, Spyridon A. Mastroyannis, Emily M. Ko & Nawar A. Latif

Authors
  1. Dimitrios Nasioudis
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  2. Spyridon A. Mastroyannis
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  3. Emily M. Ko
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  4. Nawar A. Latif
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Contributions

DN: Conception, Protocol/project development, Data collection and management, Data analysis, Manuscript writing/editing, SAM: Data analysis, Manuscript writing/editing, EMK: Data analysis, Manuscript writing/editing, NAL: Protocol/project development, Data analysis, Manuscript writing/editing.

Corresponding author

Correspondence to Dimitrios Nasioudis.

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Conflict of interest

All authors declare no potential conflict of interest, including and financial or personal relationship which could viewed as one.

Ethical standards

The SEER is a public dataset available to the public for research purpose. All patient data are de-identified. The present study was deemed exempt by the institutional review board.

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Nasioudis, D., Mastroyannis, S.A., Ko, E.M. et al. Does tumor grade influence the rate of lymph node metastasis in apparent early stage ovarian cancer?. Arch Gynecol Obstet 298, 179–182 (2018). https://doi.org/10.1007/s00404-018-4789-2

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  • DOI: https://doi.org/10.1007/s00404-018-4789-2

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