Intermediate trophoblastic tumor: the clinical analysis of 62 cases and prognostic factors

  • Ying Zhang
  • Shiqian ZhangEmail author
  • Wenqian Huang
  • Tingting Chen
  • Hang Yuan
  • Yumin Zhang
Gynecologic Oncology



The aim is to analyze the clinical characteristics of intermediate trophoblastic tumor (ITT).


12 cases diagnosed at Qilu Hospital of Shandong University from January 2005 to December 2016 were investigated. Additionally, 50 cases were selected from MEDLINE and CBM databases between January 2010 and December 2016. The clinical data extracted from those aforementioned 62 cases were analyzed.


There were 42 cases with placental site trophoblastic tumor (PSTT), 19 cases with epithelioid trophoblastic tumor (ETT), and 1 case with mixed type (PSTT and ETT). No significant differences were found between PSTT and ETT in terms of age, type of antecedent pregnancy, main complaints, serum β-hCG peak, FIGO stage or prognosis. However, the interval between antecedent pregnancy and the onset was longer in ETT than in PSTT (P = 0.01). FIGO stage was irrelevant to serum β-hCG (P = 0.263). All 62 cases underwent surgeries and seven cases preserved fertility. Fifteen cases with high risk factors were not treated with adjuvant chemotherapy. Univariate analysis results showed that age ≧ 40 years, serum β-hCG peak ≧ 1000 IU/L and nonstandard treatment were associated with poor survival, but only age remained significant on multivariate analysis for ITT (P = 0.018).


PSTT and ETT have similar clinical characteristics generally. Serum β-hCG can not reflect the progress of ITT. Age ≧ 40 years is the independent high risk factor for ITT.


Intermediate trophoblastic tumor Placental site trophoblastic tumor Epithelioid trophoblastic tumor Clinical characteristics 


Author contributions

YZ, data management, data analysis and manuscript writing; SZ, project development and manuscript editing; WH, data collection; TC, data collection; HY, data collection; YZ, data collection.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Because of the retrospective study based on anonymous patient records, informed consent was not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of GynecologyJining First People’s HospitalJiningChina
  2. 2.Department of Obstetrics and GynecologyQilu Hospital of Shandong UniversityJinanChina

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