Oncotype DX® in breast cancer patients: clinical experience, outcome and follow-up—a case–control study
Breast cancer is the leading cause of death from cancer in women and the most common cancer in the world . To date, many patients with estrogen-receptor-positive (ER+) breast cancer are overtreated with chemotherapy when the rationale for adjuvant chemotherapy is based on clinicopathologic parameters. Different studies were able to demonstrate that a 21-gene expression assay (Oncotype DX® Genomic Health, Redwood City, CA) can predict the benefit from adjuvant chemotherapy in ER+ breast cancers [2, 3] and provide additional prognostic information independent of clinicopathological features .
Data from all patients with ER+ Her2neu− breast cancer undergoing Oncotype DX® testing between 2011 and 2014 at a tertiary referral center in Germany were analyzed. Oncotype DX® was performed in 69 cases, in 2 cases data were missing and in 3 cases Oncotype DX® could not be performed by the company. The results showed a low risk in 39 cases, an intermediate risk in 22 cases and a high risk in 3 cases. Based on Oncotype results, treatment recommendations were changed in 39 of 64 patients (61%). Before Oncotype DX® testing, chemotherapy was recommended in 67 patients, afterwards only in 25 patients. Data from 44 of 67 patients were matched to controls for stage, tumor grade, menopausal and hormone receptor status. Within a mean observation time of 19.7 months, cancer recurrence was observed in two patients.
Oncotype DX® testing can be recommended for risk-tailored chemotherapy. Results should be validated in larger prospective studies.
KeywordsBreast cancer Oncotype DX® Gene expression assay Case–control study
MR: project development, Data collection and analysis, manuscript writing. LU: statistics, manuscript writing. MF: data collection. JH: data analysis. MG: data analysis. CD: manuscript editing. AH: manuscript editing. SS: manuscript editing. VE: data collection. TK: Project development. CS: project development. CB: project development, manuscript editing. JR: project development manuscript writing.
Compliance with ethical standards
Conflict of interest
MRath declares that she has no conflict of interest. L Uhlmann declares that he has no conflict of interest. M Fiedler declares that she has no conflict of interest. J Heil declares that he has no conflict of interest. M Golatta declares that he has no conflict of interest. C Dinkic declares that she has no conflict of interest. A Hennigs declares that he has no conflict of interest. S Schott declares that she has no conflict of interest. V Ernst declares that she has no conflict of interest. T Koch declares that he has no conflict of interest. C Sohn declares that he has no conflict of interest. C Brucker declares that she has no conflict of interest. J Rom declares that he has no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Data were anonymized, therefore no Informed consent was necessary.
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