Archives of Gynecology and Obstetrics

, Volume 296, Issue 6, pp 1181–1188 | Cite as

High-intensity focused ultrasound (HIFU) treatment for uterine fibroids: a meta-analysis

  • Yongshuo Ji
  • Kaimeng Hu
  • Yu Zhang
  • Lijun Gu
  • Junqiu Zhu
  • Linglin Zhu
  • Yanfei Zhu
  • Hong Zhao
General Gynecology



High-intensity focused ultrasound (HIFU) is a non-invasive uterine-preserving treatment alternative to hysterectomy for women with fibroids.


We performed this meta-analysis to evaluate the efficacy of HIFU in the treatment of women with symptomatic fibroids comparing it to other approaches including medical treatment with mifepristone (Mife), traditional surgery with myomectomy or hysterectomy (MYC/HRM), and radiofrequency ablation (RF). 16 studies with 1725 women were included.


The pooled data of HIFU comparing it to other methods in terms of complete or partial response rate (CR/PR) was not significantly better, but in subgroup analysis, the response rate was significantly higher than Mife, significantly lower than RF and comparable to MYC/HRM, respectively. For the endpoints of safety, the superiority of HIFU compared to MYC/HMR or Mife was found to be significant in terms of pain/discomfort, fever, transfusion, genital tract, gastrointestinal tract, and anesthesia-related complications, while no superiority was identified for skin burn, urinary tract, and nervous system complications.


These results suggest that HIFU treatment of uterine leiomyomas leads to clinical improvement with few significant clinical complications and adverse events.


HIFU Uterine fibroids Myomectomy Hysterectomy Mifepristone Radiofrequency ablation 


Author contributions

Conceived and designed the experiment: KH and HZ. Extracted data: YZ, LG, JZ, and HZ. Performed the data analyses: LZ and YZ. Wrote the paper: YJ and KH.

Compliance with ethical standards


This study was not funded.

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors. This concerns a systematic review.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of TumorHuadong Hospital Affiliated to Fudan UniversityShanghaiChina
  2. 2.Shanghai A&S Science Technology Development Co., LtdShanghaiChina
  3. 3.Department of Obstetrics and GynecologyShanghai Ninth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina

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