Archives of Gynecology and Obstetrics

, Volume 296, Issue 3, pp 475–482 | Cite as

Maternal serum homocysteine and uterine artery Doppler as predictors of preeclampsia and poor placentation

  • Ahmed M. Maged
  • Hany Saad
  • Hadeer Meshaal
  • Emad Salah
  • Suzy Abdelaziz
  • Eman Omran
  • Wesam S. Deeb
  • Maha Katta
Maternal-Fetal Medicine



The aim of this study was to evaluate the role of maternal serum total Homocysteine (tHcy) and uterine artery (Ut-A) Doppler as predictors of preeclampsia (PE), intrauterine growth restriction (IUGR), and other complications related to poor placentation.

Patients and methods

A prospective cohort study was conducted on 500 women with spontaneous pregnancies. tHcy was measured at 15–19 weeks, and then, Ut-A Doppler was performed at 18–22 weeks of pregnancy.


453 pregnant women completed the follow-up of the study. The tHcy and Ut-A resistance index were significantly higher in women who developed PE, IUGR, and other complications when compared to controls (tHcy: 7.033 ± 2.744, 6.321 ± 3.645, and 6.602 ± 2.469 vs 4.701 ± 2.082 μmol/L, respectively, p value <0.001 and Ut-A resistance index: 0.587 ± 0.072, 0.587 ± 0.053, and 0.597 ± 0.069 vs 0.524 ± 0.025, respectively, p value <0.001). The use of both tHcy assessment and Ut-A Doppler improved the sensitivity of prediction of PE relative to the use of each one alone (85.2 relative to 73.33 and 60%, respectively).


The use of elevated homocysteine and uterine artery Doppler screening are valuable in prediction of preeclampsia, IUGR, and poor placentation disorders. ID



Homocysteine Uterine artery Doppler Preeclampsia Poor placentation disorders 


Author contribution statement

AMM: project development, data collection, and manuscript writing; HS: data collection; HM: data collection; ES: data collection; SA: manuscript writing and data collection; EO: data collection, data analysis, and manuscript writing; WD: manuscript writing; MK: manuscript writing.

Compliance with ethical standards

Ethical standards

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The author reports no conflicts of interest in this work.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Ahmed M. Maged
    • 1
  • Hany Saad
    • 1
  • Hadeer Meshaal
    • 1
  • Emad Salah
    • 1
  • Suzy Abdelaziz
    • 1
  • Eman Omran
    • 1
  • Wesam S. Deeb
    • 2
  • Maha Katta
    • 3
  1. 1.Obstetrics and Gynecology DepartmentCairo UniversityGizaEgypt
  2. 2.Department of Obstetrics and Gynecology, Faculty of MedicineFayoum UniversityFayoumEgypt
  3. 3.Department of Obstetrics and Gynecology, Faculty of MedicineBeniSuef UniversityBeni SuefEgypt

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