Use of complementary and integrative medicine among German breast cancer patients: predictors and implications for patient care within the PRAEGNANT study network
- 347 Downloads
The present study aims to analyze a cohort of advanced breast cancer patients in Germany to assess their interest in complementary and alternative medicine (CAM) and patient’s use of most frequent CAM methods.
Patients and methods
Based on the PREGNANT real-time breast cancer registry which is a multicenter study in Germany, questionnaires of 580 patients with advanced breast cancer were evaluated. The implemented questionnaire for CAM asked for general interest in CAM and for patient’s use of different CAM methods at present and in the past. The interest and application of CAM were analyzed for association with patients’ characteristics such as tumor, patient, and therapy characteristics.
In total, 436 out of 580 (75%) patients claimed to be interested in CAM. Further, interest in CAM is significantly correlated with younger age and absence of metastasis at the time of diagnosis. Multivariate analysis confirmed the patient’s age and distant disease status at the time of diagnosis as related to interest in CAM. A total of 56.4% of patients applied any CAM method in the past. Moreover, with increasing lines of therapies, the more frequent use of CAM was observed. Hereby, praying, vitamin supplements, and other food supplements were most frequently applied.
Our data demonstrate high overall interest and frequent use of CAM in advanced breast cancer patients supporting a strong demand of breast cancer patients for complementary counseling and treatments additional to the established cancer therapies. It is indispensable to implement counseling and evidence-based complementary treatments into clinical routine of cancer centers and to adapt postgraduate medical education, respectively.
KeywordsIntegrative medicine Complementary medicine Alternative medicine Breast cancer Oncology
The PRAEGNANT network is supported by grants from Novartis and Pfizer.
CF, CH, and MW designed the project and wrote the manuscript. PF contributed to concept, drafting, analysis, and interpretation of data. On behalf of the PREAGNANT Study Network, all authors collected data. GR conducted statistical analysis. All authors read and approved the final version.
Compliance with ethical standards
Conflict of interest
Author Peter Fasching received research grants from Amgen, Celgene, and Novartis and honoraria from Novartis, Pfizer, Celgene, and Roche. Author Diana Lüftner received honoraria from Amgen, Celgene, and Novartis. All other authors declare they have no conflict of interest to disclose.
The study has been approved by the ethical review board of all participating sites, and all investigations were conducted according to the declaration of Helsinki. In line with this notion, all patients provided their written informed consent.
- 1.Molassiotis A, Fernadez-Ortega P, Pud D, Ozden G, Scott JA, Panteli V, Margulies A, Browall M, Magri M, Selvekerova S, Madsen E, Milovics L, Bruyns I, Gudmundsdottir G, Hummerston S, Ahmad AM-A, Platin N, Kearney N, Patiraki E (2005) Use of complementary and alternative medicine in cancer patients: a European survey. Ann Oncol 16:655–663CrossRefPubMedGoogle Scholar
- 14.Kalder M, Muller T, Fischer D, Muller A, Bader W, Beckmann MW, Brucker C, Hack CC, Hanf V, Hasenburg A, Hein A, Jud S, Kiechle M, Klein E, Paepke D, Rotmann A, Schutz F, Dobos G, Voiss P, Kummel S (2016) A review of integrative medicine in gynaecological oncology. Geburtshilfe Frauenheilkd 76:150–155CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Hack CC, Beckmann MW, Hein A, Bayer CM, Rauh C, Almstedt K, Hüttner NBM, Janni W, Fehm T, Maass N, Rody A, Fersis N, Wallwiener D, Hübner J, Fasching PA (2014) Application of integrative medicine by postmenopausal breast cancer patients in the PreFace Phase IV study - a prospective, longitudinal trial. Oncol Res Treat 37(suppl 1):1–132Google Scholar
- 18.Hack CC, Fasching PA, Fehm T, de Waal J, Rezai M, Baier B, Baake G, Kolberg H-C, Guggenberger M, Warm M, Harbeck N, Wuerstlein R, Deuker J-U, Dall P, Richter B, Wachsmann G, Brucker C, Siebers JW, Fersis N, Kuhn T, Wolf C, Vollert H-W, Breitbach G-P, Janni W, Landthaler R, Kohls A, Rezek D, Noesslet T, Fischer G, Henschen S, Praetz T, Heyl V, Kühn T, Krauss T, Thomssen C, Hohn A, Tesch H, Mundhenke C, Hein A, Rauh C, Bayer CM, Jacob A, Schmidt K, Belleville E, Hadji P, Brucker SY, Wallwiener D, Kümmel S, Beckmann MW, Paepke D (2016) Interest in integrative medicine among postmenopausal hormone receptor–positive breast cancer patients in the EvAluate-TM Study. Integr Cancer Ther. doi: 10.1177/1534735416668575 PubMedGoogle Scholar
- 19.Hein A, Gass P, Walter CB, Taran FA, Hartkopf A, Overkamp F, Kolberg HC, Hadji P, Tesch H, Ettl J, Wuerstlein R, Lounsbury D, Lux MP, Luftner D, Wallwiener M, Muller V, Belleville E, Janni W, Fehm TN, Wallwiener D, Ganslandt T, Ruebner M, Beckmann MW, Schneeweiss A, Fasching PA, Brucker SY (2016) Computerized patient identification for the EMBRACA clinical trial using real-time data from the PRAEGNANT network for metastatic breast cancer patients. Breast Cancer Res Treat 158:59–65CrossRefPubMedGoogle Scholar
- 20.Fasching PA, Brucker SY, Fehm TN, Overkamp F, Janni W, Wallwiener M, Hadji P, Belleville E, Haberle L, Taran FA, Luftner D, Lux MP, Ettl J, Muller V, Tesch H, Wallwiener D, Schneeweiss A (2015) Biomarkers in patients with metastatic breast cancer and the PRAEGNANT study network. Geburtshilfe Frauenheilkd 75:41–50CrossRefPubMedPubMedCentralGoogle Scholar
- 24.Nicolaisen-Murmann K, Thiel F, Mohrmann S, Grünewald E, Ackermann S, Bender HG, Beckmann MW, Fasching PA (2005) Complementary and alternative medicine in women with gynecological and breast malignancies—a multicenter study exploring prevalence and motivation. Geburtshilfe Frauenheilkd 65:178–185CrossRefGoogle Scholar