Archives of Gynecology and Obstetrics

, Volume 295, Issue 3, pp 721–729 | Cite as

Dietary vitamin B2 intake and breast cancer risk: a systematic review and meta-analysis

  • Lanting YuEmail author
  • Yuyan Tan
  • Lin Zhu
Gynecologic Oncology



Epidemiological studies assessing the relationship between dietary vitamin B2 and the risk of breast cancer have produced inconsistent results. Thus, we conducted this meta-analysis of epidemiologic studies to evaluate this association.


We searched English-language MEDLINE publications and conducted a manual search to screen eligible articles. A random-effect model was used to pool study-specific risk estimates. Egger’s linear regression test was also used to detect publication bias in meta-analysis.


In our meta-analysis, ten studies comprising totally 12,268 breast cancer patients were available in the analyses. Pooled relative risk (RR) comparing the highest to the lowest vitamin B2 intake and breast cancer incidence was 0.85 [95% confidence interval (CI) = 0.76–0.95]. No significant heterogeneity existed across the studies (P = 0.086, I 2 = 40.7%). No publication bias was found. The results of dose–response analysis also showed that an increment of 1 mg/day was inversely related to the risk of breast cancer (RR = 0.94; 95% CI = 0.90–0.99).


Results from our meta-analysis indicated that dietary vitamin B2 intake is weakly related to the reduced risk of breast cancer. Additional research is also necessary to further explore this association.


Vitamin B2 Meta-analysis Breast cancer Risk 


Compliance with ethical standards

Conflict of interest

Author Lanting Yu declares that he/she has no conflict of interest. Author Yuyan Tan Lin Zhu declares that he/she has no conflict of interest. Author Lin Zhu declares that he/she has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of SurgeryChangsha Hospital for Maternal and Child Health CareChangshaChina
  2. 2.Departments of General Surgery, The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangChina
  3. 3.Departments of General SurgeryThe Fourth Affiliated Hospital ZheJiang University School of MedicineYiwuChina

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