Archives of Gynecology and Obstetrics

, Volume 295, Issue 1, pp 233–238 | Cite as

Ovarian reserve in women with a previous history of severe pre-eclampsia

  • Priya BhideEmail author
  • Åse Vårtun
  • Berit Aune
  • Kari Flo
  • Purusotam Basnet
  • Ganesh Acharya
Gynecologic Endocrinology and Reproductive Medicine



Severe pre-eclampsia affects maternal health with long-term consequences. It is postulated that during the process of implantation and cell differentiation, embryos resulting from the fertilization of ageing oocytes produce malfunctioning trophoectoderm leading to placental dysfunction. Therefore, severe pre-eclampsia may be associated with a decreased ovarian reserve. The objective of this study was to compare serum markers of ovarian reserve and function between women who had severe pre-eclampsia and those who had normal pregnancies.


Twenty women who had severe pre-eclampsia (PE) and 20 who had uncomplicated pregnancies (controls) matched for age and body mass index were included in the study. Fasting blood samples were taken during the follicular phase (day 5) of the menstrual cycle 6 months to 5 years after the delivery. Serum was separated and frozen at −70 °C until analyzed for anti-Mϋllerian hormone (AMH), total and free testosterone (TT), free-androgen index (FAI), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) hormone to evaluate ovarian reserve and function, and the results were compared between two groups.


The median AMH was 0.91 ng/mL in PE group compared to 0.72 ng/mL in controls (p = 0.995). No significant differences were found between the two groups in the levels of LH (5.65 vs. 5.4 IU/L, respectively, p = 0.897) and FSH (4.95 vs. 5.1 IU/L, respectively, p = 0.523). However, total and free-TT levels as well as FAI were significantly lower in the PE group compared to controls (p = 0.017, p = 0.006, and p = 0.011, respectively).


Ovarian reserve and function are not altered significantly in women with a previous history of pre-eclampsia compared with women who had an uncomplicated pregnancy.


Ovarian reserve Severe pre-eclampsia 



This study was partly funded by the Regional Health Authority of Northern Norway.

Compliance with ethical standards

Conflict of interest

P. Bhide declares that she has no conflict of interest. A. Vartun declares that she has no conflict of interest. B. Aune declares that she has no conflict of interest. K. Flo declares that she has no conflict of interest. P. Basnet declares that he has no conflict of interest. G. Acharya declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Priya Bhide
    • 1
    Email author
  • Åse Vårtun
    • 2
  • Berit Aune
    • 2
    • 3
  • Kari Flo
    • 2
    • 3
  • Purusotam Basnet
    • 2
    • 3
  • Ganesh Acharya
    • 2
    • 3
  1. 1.Homerton Fertility CentreHomerton University Hospital NHS Foundation TrustLondonUK
  2. 2.Women’s Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health SciencesUniversity of TromsøTromsøNorway
  3. 3.Department of Obstetrics and GynecologyUniversity Hospital of North NorwayTromsøNorway

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