Archives of Gynecology and Obstetrics

, Volume 293, Issue 5, pp 959–966 | Cite as

Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis

Review

Abstract

Purpose

Vitamin D is widely used for bone growth and normal insulin secretion; however, the association between vitamin D status and gestational diabetes risk is controversial. This meta-analysis aimed to quantitatively evaluate the association between vitamin status and risk of gestational diabetes.

Methods

We performed a systematic search on the PubMed, EmBase, and Cochrane Library databases in January 2015 to obtain observational studies studying gestational diabetes risk in relation to vitamin D status. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to measure the association between vitamin D status and the risk of gestational diabetes.

Results

A total of 20 observational studies were included in the final analysis containing 16,515 individuals. Overall, maternal vitamin D insufficiency was found to be associated with a greater risk of gestational diabetes (RR 1.45; 95 % CI 1.15–1.83; P < 0.001). Subgroup analysis indicated that this association might differ based on countries, study design, assessment of vitamin D levels, sample size, age at baseline, adjusted models, and study quality.

Conclusions

This meta-analysis revealed that maternal vitamin D insufficiency is associated with increased risk of gestational diabetes.

Keywords

Association Gestational diabetes Meta-analysis Vitamin D status 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Clinical LaboratoryThe First Affiliated Hospital of Anhui Medical UniversityHefeiChina

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