Archives of Gynecology and Obstetrics

, Volume 294, Issue 1, pp 71–76 | Cite as

Uterine artery embolization combined with curettage vs. methotrexate plus curettage for cesarean scar pregnancy

  • Wei LiuEmail author
  • Liang Shen
  • Qingwen Wang
  • Wei Wang
  • Zengtao Sun
Maternal-Fetal Medicine



To compare the efficacy and safety of uterine artery embolization (UAE) combined with curettage and methotrexate (MTX) plus curettage in the treatment of cesarean scar pregnancy (CSP).


From January 2005 to December 2013, we treated 38 CSP patients with UAE combined with curettage, and another 26 patients with CSP were treated with methotrexate (MTX) plus curettage. The resulting data were analyzed statistically.


The median volume of blood loss was 17.5 ml in the UAE combined with curettage (UAE-C) group vs. 335 ml in the MTX plus curettage (MTX-C) group (p < 0.001). The time from the procedure till β-human chorionic gonadotropin (β-hCG) concentration returned to normal was 25.13 ± 3.74 days in the UAE-C group vs. 56.15 ± 15.99 days in the MTX-C group (p < 0.001). The duration of hospitalization was 7.44 ± 1.92 vs. 19.38 ± 8.75 days, respectively (p < 0.001). The percentage of side effects in the UAE-C group was significantly lower than in the MTX-C group.


UAE combined with curettage appears to be superior to MTX plus curettage for treatment of CSP with high serum β-hCG level, though prospective trials are needed.


Cesarean scar pregnancy Treatment Uterine artery embolization Curettage Methotrexate 



This study was supported by a grant from the Science and Technology Research Projects of the Population and Family Planning Commission of Shandong, China (no. 9 2012;) and by funds from the Shandong Science and Technology Development Plans (2013GSF11907 and 2014GGH218027).

Compliance with ethical standards

Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Wei Liu
    • 1
    Email author
  • Liang Shen
    • 1
  • Qingwen Wang
    • 2
  • Wei Wang
    • 3
  • Zengtao Sun
    • 2
  1. 1.Department of GynecologyShandong Provincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  2. 2.Department of Interventional RadiologyShandong Medical Imaging Research InstituteJinanPeople’s Republic of China
  3. 3.Department of UltrasoundShandong Provincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China

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