Archives of Gynecology and Obstetrics

, Volume 292, Issue 6, pp 1279–1284 | Cite as

Pycnogenol prevents peritoneal adhesions

  • Ahmet SahbazEmail author
  • Oner Aynioglu
  • Hatice Isik
  • Banu Dogan Gun
  • Osman Cengil
  • Onur Erol
General Gynecology



This study tested the ability of pycnogenol, an extract from the bark of the French maritime pine (Pinus pinaster), to prevent intra-abdominal adhesions.


Thirty female Wistar albino rats were separated randomly into three equal groups: Group (1) the control group, which underwent surgery, but was given no drug; Group (2) given 10 mg/kg of pycnogenol dissolved in normal saline intraperitoneally for 10 days after surgery; and Group (3) given 0.1 mL of normal saline for 10 days intraperitoneally after surgery. On post-operative day 10, all of the animals were killed and any adhesions were evaluated macroscopically and histopathologically.


The macroscopic adhesion scores (mean ± SD) for Groups 1, 2, and 3 were 2.5 ± 0.53, 0.60 ± 0.70, and 2.0 ± 0.82, respectively. The macroscopic adhesion score was significantly lower in Group 2 than in Groups 1 and 3 (p < 0.001). All three components of the histopathological evaluation (inflammation, fibrosis, and neovascularization) were significantly lower in Group 2 than in Groups 1 or 3 (p < 0.001, p < 0.001, and p = 0.004, respectively).


Pycnogenol was found to be effective at preventing surgery-related adhesions in an animal model.


Pycnogenol Intra-abdominal Adhesions Female Rat 



We thank Assistant Professor Furuzan Kokturk, Bulent Ecevit University School of Medicine, Department of Biostatistics, for the statistical analysis of the data, and Doctor Humeyra Cicekler for her technical support.

Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Ahmet Sahbaz
    • 1
    Email author
  • Oner Aynioglu
    • 1
  • Hatice Isik
    • 1
  • Banu Dogan Gun
    • 2
  • Osman Cengil
    • 3
  • Onur Erol
    • 4
  1. 1.School of Medicine, Department of Obstetrics and GynecologyZonguldak Bulent Ecevit UniversityZonguldakTurkey
  2. 2.School of Medicine, Department of PathologyZonguldak Bulent Ecevit UniversityZonguldakTurkey
  3. 3.Experimental Animal Research Laboratory, School of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey
  4. 4.Department of Gynecological OncologyAntalya Education and Research HospitalAntalyaTurkey

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