Advertisement

Archives of Gynecology and Obstetrics

, Volume 291, Issue 5, pp 1037–1040 | Cite as

Umbilical cord blood adipokines and newborn weight change

  • Maria João FonsecaEmail author
  • Ana Cristina Santos
Maternal-Fetal Medicine

Abstract

Purpose

To ascertain the association between umbilical cord levels of adiponectin, leptin and resistin, and birth weight (BW) and newborn weight change (NWC) in the first 96 h of life.

Methods

392 full-term singletons were recruited, in 2005/2006, at the five public units providing obstetrical and neonatal care in Porto. Information was collected by face-to-face interview and additionally from clinical records. Umbilical cord blood adipokines levels were determined and categorized using the 10th and 90th percentiles. Anthropometrics were obtained by trained examiners and NWC estimated as (weight − BW)/BW × 100, adjusted for newborn’s age. Regression coefficients and 95 % confidence intervals were calculated.

Results

Low leptin levels (≤5.6 ng/ml) were associated with lower BW (β = −137.3 g 95 %CI −268.6 g, −6.1 g) and high leptin levels (≥30.7 ng/ml) were associated with higher BW (β = 276.3 g 95 %CI 145.8 g, 406.8 g) and higher NWC (β = 1.10 % 95 % CI 0.29 %, 1.92 %), comparing to newborns with normal leptin levels. Adiponectin and resistin were not associated with BW or NWC.

Conclusion

High umbilical cord blood leptin levels predicted higher BW and lower weight loss in the immediate postnatal period.

Keywords

Adiponectin Leptin Resistin Umbilical cord blood Newborn weight loss 

Notes

Acknowledgments

The authors gratefully acknowledge the families enrolled in Generation XXI for their kindness, all members of the research team for their enthusiasm and perseverance and the participating hospitals and their staff for their help and support. Generation XXI was funded by Programa Operacional de Saúde–Saúde XXI, Quadro Comunitário de Apoio III and Administração Regional de Saúde Norte (Regional Department of Ministry of Health). It has support from the Portuguese Foundation for Science and Technology (SFRH/BD/69945/2010 and F-COMP-01-0124-FEDER-01108; PTDC/SAU-ESA/105033/2008) and from the Calouste Gulbenkian Foundation.

Conflict of interest

We declare that we have no conflict of interest.

References

  1. 1.
    Tsai PJ, Yu CH, Hsu SP, Lee YH, Chiou CH, Hsu YW, Ho SC, Chu CH (2004) Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clin Endocrinol (Oxf) 61(1):88–93CrossRefGoogle Scholar
  2. 2.
    Cortelazzi D, Corbetta S, Ronzoni S, Pelle F, Marconi A, Cozzi V, Cetin I, Cortelazzi R, Beck-Peccoz P, Spada A (2007) Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clin Endocrinol (Oxf) 66(3):447–453CrossRefGoogle Scholar
  3. 3.
    Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA (2002) Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 87(10):4652–4656CrossRefPubMedGoogle Scholar
  4. 4.
    Kahveci H, Laloglu F, Kilic O, Ciftel M, Kara M, Laloglu E, Yildirim A, Orbak Z, Ertekin V, Cesur Y (2014) Fasting and postprandial glucose, insulin, leptin, and ghrelin values in preterm babies and their mothers: relationships among their levels, fetal growth, and neonatal anthropometry. J Matern Fetal Neonatal Med 28:1–6Google Scholar
  5. 5.
    Noel-Weiss J, Courant G, Woodend AK (2008) Physiological weight loss in the breastfed neonate: a systematic review. Open Med 2(4):e99–e110PubMedCentralPubMedGoogle Scholar
  6. 6.
    Larsen PS, Kamper-Jorgensen M, Adamson A, Barros H, Bonde JP, Brescianini S, Brophy S, Casas M, Charles MA, Devereux G, Eggesbo M, Fantini MP, Frey U, Gehring U, Grazuleviciene R, Henriksen TB, Hertz-Picciotto I, Heude B, Hryhorczuk DO, Inskip H, Jaddoe VW, Lawlor DA, Ludvigsson J, Kelleher C, Kiess W, Koletzko B, Kuehni CE, Kull I, Kyhl HB, Magnus P, Momas I, Murray D, Pekkanen J, Polanska K, Porta D, Poulsen G, Richiardi L, Roeleveld N, Skovgaard AM, Sram RJ, Strandberg-Larsen K, Thijs C, Van Eijsden M, Wright J, Vrijheid M, Andersen AM (2013) Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research. Paediatr Perinat Epidemiol 27(4):393–414CrossRefPubMedGoogle Scholar
  7. 7.
    Fonseca MJ, Severo M, Barros H, Santos AC (2014) Determinants of weight changes during the first 96 hours of life in full-term newborns. Birth 41(2):160–168CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.EPIUnit, Institute of Public HealthUniversity of PortoPortoPortugal
  2. 2.Department of Clinical Epidemiology, Predictive Medicine and Public HealthUniversity of Porto Medical SchoolPortoPortugal

Personalised recommendations