Archives of Gynecology and Obstetrics

, Volume 291, Issue 5, pp 1037–1040 | Cite as

Umbilical cord blood adipokines and newborn weight change

  • Maria João FonsecaEmail author
  • Ana Cristina Santos
Maternal-Fetal Medicine



To ascertain the association between umbilical cord levels of adiponectin, leptin and resistin, and birth weight (BW) and newborn weight change (NWC) in the first 96 h of life.


392 full-term singletons were recruited, in 2005/2006, at the five public units providing obstetrical and neonatal care in Porto. Information was collected by face-to-face interview and additionally from clinical records. Umbilical cord blood adipokines levels were determined and categorized using the 10th and 90th percentiles. Anthropometrics were obtained by trained examiners and NWC estimated as (weight − BW)/BW × 100, adjusted for newborn’s age. Regression coefficients and 95 % confidence intervals were calculated.


Low leptin levels (≤5.6 ng/ml) were associated with lower BW (β = −137.3 g 95 %CI −268.6 g, −6.1 g) and high leptin levels (≥30.7 ng/ml) were associated with higher BW (β = 276.3 g 95 %CI 145.8 g, 406.8 g) and higher NWC (β = 1.10 % 95 % CI 0.29 %, 1.92 %), comparing to newborns with normal leptin levels. Adiponectin and resistin were not associated with BW or NWC.


High umbilical cord blood leptin levels predicted higher BW and lower weight loss in the immediate postnatal period.


Adiponectin Leptin Resistin Umbilical cord blood Newborn weight loss 



The authors gratefully acknowledge the families enrolled in Generation XXI for their kindness, all members of the research team for their enthusiasm and perseverance and the participating hospitals and their staff for their help and support. Generation XXI was funded by Programa Operacional de Saúde–Saúde XXI, Quadro Comunitário de Apoio III and Administração Regional de Saúde Norte (Regional Department of Ministry of Health). It has support from the Portuguese Foundation for Science and Technology (SFRH/BD/69945/2010 and F-COMP-01-0124-FEDER-01108; PTDC/SAU-ESA/105033/2008) and from the Calouste Gulbenkian Foundation.

Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.EPIUnit, Institute of Public HealthUniversity of PortoPortoPortugal
  2. 2.Department of Clinical Epidemiology, Predictive Medicine and Public HealthUniversity of Porto Medical SchoolPortoPortugal

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