Archives of Gynecology and Obstetrics

, Volume 290, Issue 5, pp 929–935 | Cite as

The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome

  • Ayse Carlioglu
  • Ikbal KaygusuzEmail author
  • Feridun Karakurt
  • Ilknur Inegol Gumus
  • Aysel Uysal
  • Benan Kasapoglu
  • Ferah Armutcu
  • Sema Uysal
  • Esra Aktepe Keskin
  • Cemile Koca
General Gynecology



To evaluate the platelet activating factor acetyl hydrolyze (PAF-AH), oxidized low-density lipoprotein (ox-LDL), paraoxonase 1 (PON1), arylesterase (ARE) levels and the effects of metformin and Diane-35 (ethinyl oestradiol + cyproterone acetate) therapies on these parameters and to determine the PON1 polymorphisms among PCOS patients.


Ninety patients with PCOS, age 30, and body mass index-matched healthy controls were included in the study. Patients were divided into three groups: metformin treatment, Diane-35 treatment and no medication groups. The treatment with metformin or Diane-35 was continued for 6 months and all subjects were evaluated with clinical and biochemical parameters 6 months later. One-way Anova test, t test and non-parametric Mann–Whitney U tests were used for statistical analysis.


PAF-AH and ox-LDL levels were statistically significantly higher in untreated PCOS patients than controls, and they were statistically significantly lower in patients treated with metformin or Diane-35 than untreated PCOS patients. In contrast, there were lower PON1 (not statistically significant) and ARE (statistically significant) levels in untreated PCOS patients than the control group and they significantly increased after metformin and Diane-35 treatments. In PCOS patients serum PON1 levels for QQ, QR and RR phenotypes were statistically significantly lower than the control group.


In patients with PCOS, proatherogenic markers increase. The treatment of PCOS with metformin or Diane-35 had positive effects on lipid profile, increased PON1 level, which is a protector from atherosclerosis and decreased the proatherogenic PAF-AH and ox-LDL levels.


Polycystic ovary syndrome Platelet activating factor acetyl hydrolyze Oxidized LDL Paraoxonase1 Paraoxonase1 phenotypes Arylesterase 



This study was supported by Fatih University Foundation.

Conflict of interest

No conflict of interest is present for each author.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ayse Carlioglu
    • 1
  • Ikbal Kaygusuz
    • 2
    Email author
  • Feridun Karakurt
    • 3
  • Ilknur Inegol Gumus
    • 2
  • Aysel Uysal
    • 4
  • Benan Kasapoglu
    • 5
  • Ferah Armutcu
    • 6
  • Sema Uysal
    • 7
  • Esra Aktepe Keskin
    • 2
  • Cemile Koca
    • 8
  1. 1.Department of EndocrinologyRegional Education and Research HospitalErzurumTurkey
  2. 2.Department of Obstetrics and GynecologyTurgut Ozal University School of MedicineAnkaraTurkey
  3. 3.Department of EndocrinıologyGazi University Medical SchoolAnkaraTurkey
  4. 4.Department of Obstetrics and GynecologyEducation and Research HospitalAntalyaTurkey
  5. 5.Department of Internal MedicineTurgut Ozal University Medical SchoolAnkaraTurkey
  6. 6.Department of BiochemistryTurgut Ozal University Medical SchoolAnkaraTurkey
  7. 7.Department of BiochemistryNumune Education and Research HospitalAnkaraTurkey
  8. 8.Department of BiochemistryAtatürk Education and Research HospitalAnkaraTurkey

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