Archives of Gynecology and Obstetrics

, Volume 290, Issue 1, pp 13–20

Pathology of perinatal brain damage: background and oxidative stress markers

  • Gabriele Tonni
  • Silvia Leoncini
  • Cinzia Signorini
  • Lucia Ciccoli
  • Claudio De Felice
Review

DOI: 10.1007/s00404-014-3208-6

Cite this article as:
Tonni, G., Leoncini, S., Signorini, C. et al. Arch Gynecol Obstet (2014) 290: 13. doi:10.1007/s00404-014-3208-6

Abstract

Purpose

To review historical scientific background and new perspective on the pathology of perinatal brain damage. The relationship between birth asphyxia and subsequent cerebral palsy has been extensively investigated. The role of new and promising clinical markers of oxidative stress (OS) is presented.

Methods

Electronic search of PubMed-Medline/EMBASE database has been performed. Laboratory and clinical data involving case series from the research group are reported.

Results

The neuropathology of birth asphyxia and subsequent perinatal brain damage as well as the role of electronic fetal monitoring are reported following a review of the medical literature.

Conclusions

This review focuses on OS mechanisms underlying the neonatal brain damage and provides different perspective on the most reliable OS markers during the perinatal period. In particular, prior research work on neurodevelopmental diseases, such as Rett syndrome, suggests the measurement of oxidized fatty acid molecules (i.e., F4-Neuroprostanes and F2-Dihomo-Isoprostanes) closely related to brain white and gray matter oxidative damage.

Keywords

Birth asphyxia Perinatal brain damage Cerebral palsy Electronic fetal monitoring Oxidative stress 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Gabriele Tonni
    • 1
  • Silvia Leoncini
    • 2
    • 3
  • Cinzia Signorini
    • 2
  • Lucia Ciccoli
    • 2
  • Claudio De Felice
    • 4
  1. 1.Prenatal Diagnostic ServiceGuastalla Civil Hospital, AUSL Reggio EmiliaGuastallaItaly
  2. 2.Department of Molecular and Developmental MedicineUniversity of SienaSienaItaly
  3. 3.Child Neuropsychiatry UnitUniversity Hospital Azienda Ospedaliera Universitaria Senese (AOUS)SienaItaly
  4. 4.Neonatal Intensive Care UnitUniversity Hospital Azienda Ospedaliera Universitaria Senese AOUSSienaItaly

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