Archives of Gynecology and Obstetrics

, Volume 290, Issue 1, pp 131–134 | Cite as

Steroid cell tumor of the ovary in a pregnant woman whose androgenic symptoms were masked by pregnancy

  • Murat Öz
  • Emre Özgü
  • Mengü Türker
  • Salim Erkaya
  • Tayfun Güngör
Gynecologic Oncology



Ovarian steroid cell tumors are very rare sex cord-stromal tumors, and most of them are unilateral and almost one-third of the cases are malignant.

Case Report

Here, we present a pregnant woman, who diagnosed with steroid cell tumor of the ovary and underwent surgical staging.


We will discuss the clinical presentation of the case, management options and follow-up strategies.


Steroid cell tumor Sex cord-stromal tumor Virilization Ovarian mass in pregnancy 


Conflict of interest

The authors certify that no conflict of interest in relation to this article exists.


  1. 1.
    Kim YT, Kim SW, Yoon BS, Kim SH, Kim JH, Kim JW et al (2007) An ovarian steroid cell tumor causing virilization and massive ascites. Yonsei Med J 48(1):142–146PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Selvaggi SM (2000) Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. Arch Pathol Lab Med 124(3):477PubMedGoogle Scholar
  3. 3.
    Jiang W, Tao X, Fang F, Zhang S, Xu C (2013) Benign and malignant ovarian steroid cell tumors, not otherwise specified: case studies, comparison, and review of the literature. J Ovarian Res 6(1):53PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Scully R (1979) Tumors of the ovary and maldeveloped; Atlas of Tumor Pathology, vol pt 16, 2nd edn. Armed Forces Institute of Pathology, Washington, pp 215–220Google Scholar
  5. 5.
    Wang PH, Chao HT, Lee RC, Lai CR, Lee WL, Kwok CF et al (1998) Steroid cell tumors of the ovary: clinical, ultrasonic, and MRI diagnosis–a case report. Eur J Radiol 26(3):269–273PubMedCrossRefGoogle Scholar
  6. 6.
    Boyraz G, Selcuk I, Yusifli Z, Usubutun A, Gunalp S (2013) Steroid cell tumor of the ovary in an adolescent: a rare case report. Case Rep Med 2013:527698PubMedCentralPubMedGoogle Scholar
  7. 7.
    Zhao C, Vinh TN, McManus K, Dabbs D, Barner R, Vang R (2009) Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. Am J Surg Pathol 33(3):354–366PubMedCrossRefGoogle Scholar
  8. 8.
    Vulink AJ, Vermes I, Kuijper P, ten Cate LN, Schutter EM (2004) Steroid cell tumour not otherwise specified during pregnancy: a case report and diagnostic work-up for virilisation in a pregnant patient. Eur J Obstet Gynecol Reprod Biol 112(2):221–227PubMedCrossRefGoogle Scholar
  9. 9.
    Reedy MB, Richards WE, Ueland F, Uy K, Lee EY, Bryant C et al (1999) Ovarian steroid cell tumors, not otherwise specified: a case report and literature review. Gynecol Oncol 75(2):293–297PubMedCrossRefGoogle Scholar
  10. 10.
    Hayes MC, Scully RE (1987) Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases. Am J Surg Pathol 11(11):835–845PubMedCrossRefGoogle Scholar
  11. 11.
    Brewer CA, Shevlin D (1998) Encouraging response of an advanced steroid-cell tumor to GnRH agonist therapy. Obstet Gynecol 92(4 Pt 2):661–663PubMedCrossRefGoogle Scholar
  12. 12.
    Li Y, Guo DH (2009) Ovarian steroid cell tumor: clinicopathologic study of 6 cases. Zhonghua Bing Li Xue Za Zhi 38(9):621–622PubMedGoogle Scholar
  13. 13.
    Jones MW, Harri R, Dabbs DJ, Carter GJ (2010) Immunohistochemical profile of steroid cell tumor of the ovary: a study of 14 cases and a review of the literature. Int J Gynecol Pathol 29(4):315–320PubMedGoogle Scholar
  14. 14.
    Sielert L, Liu C, Nagarathinam R, Craig LB (2013) Androgen-producing steroid cell ovarian tumor in a young woman and subsequent spontaneous pregnancy. J Assist Reprod Genet 30(9):1157–1160PubMedCrossRefGoogle Scholar
  15. 15.
    McClamrock HD, Adashi EY (1992) Gestational hyperandrogenism. Fertil Steril 57(2):257–274PubMedGoogle Scholar
  16. 16.
    Lo JC, Schwitzgebel VM, Tyrrell JB, Fitzgerald PA, Kaplan SL, Conte FA et al (1999) Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab 84(3):930–936PubMedGoogle Scholar
  17. 17.
    Liu AX, Sun J, Shao WQ, Jin HM, Song WQ (2005) Steroid cell tumors, not otherwise specified (NOS), in an accessory ovary: a case report and literature review. Gynecol Oncol 97(1):260–262PubMedCrossRefGoogle Scholar
  18. 18.
    Young RH, Dudley AG, Scully RE (1984) Granulosa cell, Sertoli-Leydig cell, and unclassified sex cord-stromal tumors associated with pregnancy: a clinicopathological analysis of thirty-six cases. Gynecol Oncol 18(2):181–205PubMedCrossRefGoogle Scholar
  19. 19.
    Nichols CR, Catalano PJ, Crawford ED, Vogelzang NJ, Einhorn LH, Loehrer PJ (1998) Randomized comparison of cisplatin and etoposide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study. J Clin Oncol 16(4):1287–1293PubMedGoogle Scholar
  20. 20.
    Wang PH, Chao HT, Lee WL (1998) Use of a long-acting gonadotropin-releasing hormone agonist for treatment of steroid cell tumors of the ovary. Fertil Steril 69(2):353–355PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Murat Öz
    • 1
    • 3
  • Emre Özgü
    • 1
  • Mengü Türker
    • 2
  • Salim Erkaya
    • 1
  • Tayfun Güngör
    • 1
  1. 1.Department of Gynaecological OncologyZekai Tahir Burak Women’s Health HospitalAnkaraTurkey
  2. 2.Department of PathologyZekai Tahir Burak Women’s Health HospitalAnkaraTurkey
  3. 3.AnkaraTurkey

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