Archives of Gynecology and Obstetrics

, Volume 289, Issue 6, pp 1337–1340 | Cite as

Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study

  • Özgür Bilgin Yiyenoğlu
  • Mete Gürol Uğur
  • Hüseyin Çağlayan Özcan
  • Günay Can
  • Ebru Öztürk
  • Özcan Balat
  • Özcan Erel
Gynecologic Endocrinology and Reproductive Medicine



To determine the levels of oxidative stress markers in recurrent pregnancy loss using a novel automated method.

Materials and methods

30 pregnant women in their first trimester with a history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. Total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in maternal serum were measured using the more recently designated Erel method.


We observed statistically significant increased TOL and OSI levels in patient group (p = 0.032, p = 0.007, respectively). We also demonstrated statistically significant decreased TAC in pregnant women who had a history of RPL (p = 0.013).


Our results support the concept that oxidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAC, TOL, OSI levels using Erel method are needed.


Recurrent pregnancy loss Oxidative stress Total oxidant level Total antioxidant level 


Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Özgür Bilgin Yiyenoğlu
    • 1
  • Mete Gürol Uğur
    • 1
    • 3
  • Hüseyin Çağlayan Özcan
    • 1
  • Günay Can
    • 1
  • Ebru Öztürk
    • 1
  • Özcan Balat
    • 1
  • Özcan Erel
    • 2
  1. 1.Department of OB&GYN, Faculty of MedicineGaziantep UniversitySahinbeyTurkey
  2. 2.Department of Clinical BiochemistryAnkara Atatürk Training and Research HospitalAnkaraTurkey
  3. 3.Tip Fakultesi, Kadin Hastaliklari ve Dogum Anabilim Dali, Sahinbey Uygulama ve Arastirma HastanesiGaziantep UniversitesiSahinbeyTurkey

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