Archives of Gynecology and Obstetrics

, Volume 289, Issue 1, pp 49–53 | Cite as

Obstetric outcomes and prognostic factors of lupus pregnancies

  • Riza Madazli
  • Mehmet Aytac Yuksel
  • Mahmut Oncul
  • Metehan Imamoglu
  • Handan Yilmaz
Maternal-Fetal Medicine
First Online:
Received:
Accepted:

Abstract

Purpose

To determine maternal and fetal outcomes in pregnancies with Systemic Lupus Erythematosus (SLE), and to evaluate the prognostic factors that may affect obstetrical outcomes.

Methods

Sixty-five consecutive cases of SLE and pregnancy were included in this retrospective clinical study, performed in a university hospital which is also a reference center for SLE. Lupus pregnancies followed and delivered during the period from 2002 to 2011 in our department are evaluated. Obstetric outcomes and prognostic factors were main outcome measures.

Results

The mean patient age was 28.8 years and the nulliparity rate was 43.1 %. Disease flare-up occurred in 7.7 % of patients. Lupus anticoagulants, anticardiolipin IgG and IgM antibodies were positive in 27.6, 15.3 and 13.8 % of patients, respectively. Mean gestational age at delivery was 36.6 ± 4.2 and mean birth weight was 2,706 ± 927 g. Stillbirth, fetal growth restriction, preeclampsia and preterm delivery rates were 4.6, 18.5, 9.2 and 27.6 %, respectively. Cases with uterine artery Doppler abnormalities had significantly poorer obstetric outcomes.

Conclusions

Multidisciplinary approach to the care of pregnant women with SLE is mandatory for good maternal and fetal outcomes. Uterine artery Doppler seems to be a good prognostic factor for adverse obstetric outcomes.

Keywords

Systemic lupus erythematosus High risk pregnancy Perinatal outcome Prognostic factors 
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Notes

Conflict of interest

We state that no conflicts of interest exist.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Riza Madazli
    • 1
  • Mehmet Aytac Yuksel
    • 1
  • Mahmut Oncul
    • 1
  • Metehan Imamoglu
    • 1
  • Handan Yilmaz
    • 1
  1. 1.Department of Obstetrics and Gynecology, Cerrahpasa School of MedicineIstanbul UniversityIstanbulTurkey

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