Archives of Gynecology and Obstetrics

, Volume 288, Issue 6, pp 1269–1274 | Cite as

Magnesium supplementation to prevent high blood pressure in pregnancy: a randomised placebo control trial

  • Maria Bullarbo
  • Natalia Ödman
  • Axel Nestler
  • Thorkild Nielsen
  • Martin Kolisek
  • Jürgen Vormann
  • Ragnar RylanderEmail author
Maternal-Fetal Medicine



To assess if hypertension during the last part of pregnancy could be prevented by magnesium supplementation.


Pregnant primagravida women from a local antenatal care unit were given an oral supply of 300 mg magnesium as citrate or placebo from pregnancy week 25 in a randomised double-blind setup. Blood pressure was recorded during pregnancy as well as pregnancy outcome.


In the magnesium-supplemented group, the average diastolic blood pressure at week 37 was significantly lower than in the placebo group (72/1.4 mean/SEM vs 77/1.4, p = 0.031). The number of women with an increase in diastolic blood pressure of ≥15 mmHg was significantly lower in the magnesium group compared with the women who received placebo (p = 0.011). There was an inverse relation between the urinary excretion of magnesium during pregnancy and the diastolic blood pressure (p = 0.005).


Magnesium supplementation prevented an increase in diastolic blood pressure during the last weeks of pregnancy. The relation between diastolic blood pressure and urinary excretion of magnesium suggests that magnesium is involved in the regulation of blood pressure and that the increase in diastolic blood pressure in pregnancy could be due to a lack of magnesium.


Pregnancy-induced hypertension Magnesium Prevention 



The study was supported by grants from the Research and Development Foundation at Södra Älvsborg, Alice Swenzon’s Foundation, Swedbank Sjuhärad Research Foundation, Sweden, and Protina GmbH, Ismaning, Germany.

Ethical Standard

Ethical committee approval was obtained (ECG T 515-10, 098-09, Ethical Committee, Gothenburg University 8 April 2009) as well as permission to register according to Swedish law on personal information. Informed consent was obtained from all participants. Registration at ISRCTN98365455.

Conflict of interest

The authors report no conflict of interest. Dr Vormann is a scientific consultant to Protina GmbH.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Maria Bullarbo
    • 1
    • 2
  • Natalia Ödman
    • 1
    • 2
  • Axel Nestler
    • 3
  • Thorkild Nielsen
    • 1
    • 2
  • Martin Kolisek
    • 3
  • Jürgen Vormann
    • 4
  • Ragnar Rylander
    • 5
    Email author
  1. 1.Department of Obstetrics and Gynaecology, at Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden
  2. 2.Department of Obstetrics and GynaecologySödra Älvsborgs HospitalBorasSweden
  3. 3.Institute of Veterinary-PhysiologyFreies UniversitätBerlinGermany
  4. 4.Institute for Prevention and NutritionIsmaningGermany
  5. 5.BioFact Environmental Health Research CenterLerumSweden

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