Archives of Gynecology and Obstetrics

, Volume 287, Issue 2, pp 351–356 | Cite as

Clear cell and papillary serous endometrial carcinomas: survival in a series of 128 cases

  • Giovanna Scarfone
  • Rita Secomandi
  • Fabio ParazziniEmail author
  • Riccardo Viganò
  • Giorgia Mangili
  • Luigi Frigerio
  • Antonella Villa
  • Saverio Tateo
  • Elena Ricci
  • Giorgio Bolis
Gynecologic Oncology



Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients’ survival in a retrospective series of 128 CC and PS endometrial cancer cases.


All women with a histologically confirmed CC and PS endometrial cancer who underwent primary surgery in five institutions in Lombardy, Italy, were eligible for this study. A total of 77 (60.2 %) were PS endometrial cancer cases, 45 (35.2 %) CC cases and 6 (4.6 %) cases had mixed CC and PS histotype.


54 (42 %) cases were diagnosed at stage I, 10 (8 %) at stage II, 47 (37 %) at stage III and 17 (13 %) at stage IV. Recurrence was observed in 49 cases (38.3 %). The median time at recurrence was 12 months (interquartile range 7–18). The rate of recurrence was 20.3 % in cases at stage I–lI and 56.2 % in cases at stage III–IV (p < 0.0001). With regard to the site of recurrence 24 recurrences were in and 52 outside the pelvis. Finally, the rate of recurrence was 32.6 % (14 cases) in CC cases, 43.1 % (31 cases) in PS cases and 66.7 % (4 cases) in cases with mixed histotype. The 5-year progression-free survival was 59.5 % (67.4 % for CC cases, 55.1 % for PS and mixed cases).


In this study including CC and PS endometrial cancers, the 5-year survival from surgery was 72.7 % and the 5-year progression-free survival was 59.5 %.


Endometrial cancer Histotype Survival 


Conflict of interest

No conflict of interest is declared.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Giovanna Scarfone
    • 1
  • Rita Secomandi
    • 1
  • Fabio Parazzini
    • 1
    Email author
  • Riccardo Viganò
    • 2
  • Giorgia Mangili
    • 2
  • Luigi Frigerio
    • 3
  • Antonella Villa
    • 3
  • Saverio Tateo
    • 4
  • Elena Ricci
    • 5
  • Giorgio Bolis
    • 1
  1. 1.Obstetric and Gynecological departmentRCCS Ospedale Maggiore Policlinico Mangiagalli Regina Elena Milano, University of MilanMilanItaly
  2. 2.Clinica Ostetrico Ginecologica, Ospedale S. RaffaeleSegrateItaly
  3. 3.Divisione di Ostetricia e Ginecologia, Ospedali RiunitiBergamoItaly
  4. 4.Clinica Ostetrico GinecologicaUniversità di PaviaPaviaItaly
  5. 5.epi2004MilanItaly

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