First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies
- 374 Downloads
To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR).
A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels.
The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among the four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3.132 ± 321 g; only one infant had FGR.
Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.
KeywordsAbortion Nutrition Preterm birth Serum folate
Conflict of interest
We declare that we have no conflict of interest.
- 6.Scott J (1984) Catabolism of folates. In: Blakley RL, Bankovic SJ (eds) Folates and pterins: chemistry and biochemistry of folates, vol 1. John Wiley, New York, pp 307–327Google Scholar
- 16.Itabashi K, Fujimura M, Kusuda S, Tamura M, Hayashi M, Takahashi T, Goishi K et al (2010) New criteria for normal birthweight according to gestational age at birth in Japanese infants. Nihon Shonika Gakkai Zasshi 114:1271–1293 (in Japanese)Google Scholar
- 21.Lwin H, Yokoyama T, Date C, Yoshiike N, Kokubo Y, Tanaka H (2002) Are the associations between life-style related factors and plasma total homocysteine concentration different according to polymorphism of 5,10-methylenetetrahydrofolate reductase gene (C677T MTHFER)? A cross-sectional study in a Japanese rural population. J Epidemiol 12:126–135PubMedCrossRefGoogle Scholar
- 31.Gebhardt GS, Sholtz CL, Hillermann R, Odendaal HJ (2001) Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction. Eur J Obstet Gynecol Reprod Biol 97:174–177PubMedCrossRefGoogle Scholar
- 33.Yila T, Sasaki S, Miyashita C, Braimoh T, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R (2012) Effects of maternal 5,10-methylenetetrahydrofolate reductase C6777T or A1298C polymorphism and tobacco smoking on infant birthweight in a Japanese population. J Epidemiol (Epub ahead of print)Google Scholar
- 34.Yamada T, Cho K, Endo T, Hanatani K, Minakami H (2009) Pregnancy outcome in women with no antenatal care in Hokkaido, Japan. Nihon Shusanki-Shinseiji Igakukai Zasshi 45:1448–1455 (in Japanese)Google Scholar