Archives of Gynecology and Obstetrics

, Volume 285, Issue 4, pp 1177–1182 | Cite as

Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen

  • Thomas FreourEmail author
  • Damien Masson
  • Lionel Dessolle
  • Dalila Allaoua
  • Thomas Dejoie
  • Sophie Mirallie
  • Miguel Jean
  • Paul Barriere
Reproductive Medicine



Smoking is known to be deleterious on female fertility and in vitro fertilization (IVF) outcome, probably partly through ovarian reserve alteration. Recently, anti-Müllerian hormone (AMH) and antral follicle count (AFC) have been shown to be the most accurate ovarian reserve markers. Here, we compared ovarian reserve markers in women undergoing IVF according to smoking status and stimulation regimen.


AFC, AMH, basal FSH, LH and estradiol, and IVF outcome were compared in 277 women undergoing IVF. Smoking status and ovarian stimulation protocol (i.e. agonists or antagonists) were recorded.


Active smoking women had lower AMH and modified follicles’ size repartition in AFC compared to non-smokers. They also experienced poorer IVF outcome with decreased ovarian response and lower pregnancy rate. This remained true in both antagonist and agonist stimulation protocol groups.


Active smoking in infertile women is associated with ovarian reserve alteration, as reflected by AFC modification and decreased serum AMH, and leads to poor prognosis in ART cycles, whatever the stimulation protocol used. Infertile women should be strongly discouraged from smoking before they start IVF cycles.


Anti-Müllerian hormone Antral follicle count In vitro fertilization Ovarian reserve Smoking 


Conflict of interest

All the authors declare they have nothing to disclose.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Thomas Freour
    • 1
    • 3
    Email author
  • Damien Masson
    • 2
  • Lionel Dessolle
    • 1
  • Dalila Allaoua
    • 1
  • Thomas Dejoie
    • 2
  • Sophie Mirallie
    • 1
  • Miguel Jean
    • 1
  • Paul Barriere
    • 1
  1. 1.Reproductive Medicine UnitUniversity Hospital of NantesNantesFrance
  2. 2.Hormonology and Biochemistry LaboratoryUniversity Hospital of NantesNantesFrance
  3. 3.Service de Médecine de la Reproduction et Biologie du développement, Hôpital Mère et EnfantCHU de NantesNantes CedexFrance

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