Archives of Gynecology and Obstetrics

, Volume 285, Issue 4, pp 973–978 | Cite as

Selective and non-selective intrauterine growth restriction in twin pregnancies: high-risk factors and perinatal outcome

  • Yu Gao
  • Zhiming He
  • Yanmin Luo
  • Hongyu Sun
  • Linhuan Huang
  • Manchao Li
  • Yi Zhou
  • Baojiang Chen
  • Qun Fang
Maternal-Fetal Medicine

Abstract

Purpose

To evaluate the high-risk factors and perinatal outcome in selective intrauterine growth restriction (sIUGR) and non-selective IUGR (non-sIUGR) in twins.

Methods

In total, 336 pairs of twins were enrolled from December 2003 to 2009. According to the birth weight, 295 pairs of twins were divided into sIUGR, non-sIUGR and normal growth groups. Maternal characteristics, complications, chorionicity, zygosity and perinatal outcomes were analyzed among the three groups.

Results

The overall IUGR incidence (including sIUGR and non-sIUGR) in twin pregnancies was 23.2%. The sIUGR incidence was ten times greater than that of non-sIUGR. Monochorionicity and monozygosity were risk factors for overall IUGR, especially for the sIUGR (P < 0.01). Pre-eclampsia was more common in sIUGR than in the normal growth group (P < 0.05). Both the sIUGR and non-sIUGR groups had more intrauterine fetal death and neonatal death than the normal growth group (P < 0.01). The sIUGR group had more brain injury than the normal growth group (P < 0.01).

Conclusion

Monochorionicity, monozygosity, pre-eclampsia were high-risk factors for IUGR in twins. Perinatal death was more prevalent in the non-sIUGR group, and neonatal brain damage was more prevalent in the sIUGR group.

Keywords

Twins Intrauterine growth restriction Risk factors Perinatal mortality 

Notes

Acknowledgments

The study was financially supported by GuangDong province Natural Science Foundation, People’s Republic of China (# 10151008901000160).

Conflict of interest

There is no conflict of interest.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Yu Gao
    • 1
  • Zhiming He
    • 1
  • Yanmin Luo
    • 1
  • Hongyu Sun
    • 2
  • Linhuan Huang
    • 1
  • Manchao Li
    • 1
  • Yi Zhou
    • 1
  • Baojiang Chen
    • 1
  • Qun Fang
    • 1
  1. 1.Department of Obstetrics and Gynecology, Fetal Medicine CenterThe 1st Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of Forensic MedicineSun Yat-Sen UniversityGuangzhouPeople’s Republic of China

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