Archives of Gynecology and Obstetrics

, Volume 284, Issue 6, pp 1473–1479 | Cite as

Relationship between endometriosis and cancer from current perspective

Gynecologic Oncology

Abstract

Purpose

To examine the current mechanisms of the increased incidence of cancer in women with endometriosis.

Methods

The synthesis and review of the relevant current literature in English language.

Results

Compared with general population, women with endometriosis have two times higher risk for developing ovarian cancer, 30% higher risk for developing breast cancer, and 40% higher risk for developing hematopoietic malignancies, mainly non-Hodgkin lymphoma.

Conclusions

Endometriosis comprises many predisposing factors including genetic, epigenetic, local environmental, hormonal, inflammatory and immunologic changes, for the development of some cancers.

Keywords

Endometriosis Cancer Genetic Epigenetic Hormone 

References

  1. 1.
    Hudelist G, Keckstein J, Wright JT (2009) The migrating adenomyoma: past views on the etiology of adenomyosis and endometriosis. Fertil Steril 92:1536–1543PubMedCrossRefGoogle Scholar
  2. 2.
    Tariverdian N, Theoharides TC, Siedentopf F et al (2007) Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach. Semin Immunopathol 29:193–210PubMedCrossRefGoogle Scholar
  3. 3.
    Karanjgaokar VC, Murphy DJ, Samra JS, Mann CH (2009) Malignant transformation of residual endometriosis after hysterectomy: a case series. Fertil Steril 92:2037.e19-21PubMedCrossRefGoogle Scholar
  4. 4.
    Vlahos NF, Kalampokas T, Fotiou S (2010) Endometriosis and ovarian cancer: a review. Gynecol Endocrinol 26:213–219PubMedCrossRefGoogle Scholar
  5. 5.
    Kauppila S, Altinörs M, Väre P, Liakka A, Knuuti E, Nissi R (2008) Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis. APMIS 116:842–845PubMedCrossRefGoogle Scholar
  6. 6.
    Efthymiou CA (2009) Endometriosis-associated intestinal tumours: a consequence of long-term unopposed oestrogen? Ann R Coll Surg Engl 91:259–260PubMedCrossRefGoogle Scholar
  7. 7.
    Manipadam MT, Munemane A, Emmanuel P, McCluggage WG (2008) Ovarian adenosarcoma with extensive deciduoid morphology arising in endometriosis: a case report. Int J Gynecol Pathol 27:398–401PubMedCrossRefGoogle Scholar
  8. 8.
    Nagle CM, Olsen CM, Webb PM, Jordan SJ, Whiteman DC, Green AC (2008) Endometrioid and clear cell ovarian cancers: a comparative analysis of risk factors. Eur J Cancer 44:2477–2484PubMedCrossRefGoogle Scholar
  9. 9.
    Orezzoli JP, Russell AH, Oliva E, Del Carmen MG, Eichhorn J, Fuller AF (2008) Prognostic implication of endometriosis in clear cell carcinoma of the ovary. Gynecol Oncol 110:336–344PubMedCrossRefGoogle Scholar
  10. 10.
    Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS (2009) Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report. J Korean Med Sci 24:767–771PubMedCrossRefGoogle Scholar
  11. 11.
    Vlahos NF, Economopoulos KP, Fotiou S (2010) Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer. Best Pract Res Clin Obstet Gynaecol 24:39–50PubMedCrossRefGoogle Scholar
  12. 12.
    Sznurkowski JJ, Emerich J (2008) Endometriomas are more frequent on the left side. Acta Obstet Gynecol Scand 87:104–106PubMedCrossRefGoogle Scholar
  13. 13.
    Nezhat F, Datta MS, Hanson V, Pejovic T, Nezhat C, Nezhat C (2008) The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril 90:1559–1570PubMedCrossRefGoogle Scholar
  14. 14.
    Brinton LA, Gridley G, Persson I, Baron J, Bergqvist A (1997) Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol 176:572–579PubMedCrossRefGoogle Scholar
  15. 15.
    Matalliotakis I, Cakmak H, Fragouli Y, Zervoudis S, Neonaki M, Arici A (2009) Association of endometriosis with family history of non-Hodgkin’s lymphoma: presentation of 10 cases. J BUON 14:699–701PubMedGoogle Scholar
  16. 16.
    Aris A (2010) Endometriosis-associated ovarian cancer: a ten-year cohort study of women living in the Estrie Region of Quebec, Canada. J Ovarian Res 3:2PubMedCrossRefGoogle Scholar
  17. 17.
    Agrawal A, Nation J, Ghatage P, Chu P, Ross S, Magliocco A (2009) Malignant chest wall endometriosis: a case report and literature review. J Obstet Gynaecol Can 31:538–541PubMedGoogle Scholar
  18. 18.
    Benoit L, Arnould L, Cheynel N et al (2006) Malignant extraovarian endometriosis: a review. Eur J Surg Oncol 32:6–11PubMedCrossRefGoogle Scholar
  19. 19.
    Wu WC, Hsiao MW, Ye JC, Hung YC, Chang WC (2009) Malignant transformation of extragonadal endometriosis: a case report. Eur J Gynaecol Oncol 30:563–565PubMedGoogle Scholar
  20. 20.
    Hiromura T, Tanaka YO, Nishioka T, Satoh M, Tomita K (2009) Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. Br J Radiol 82:e20–e22PubMedCrossRefGoogle Scholar
  21. 21.
    Bertelsen L, Mellemkjaer L, Frederiksen K et al (2007) Risk for breast cancer among women with endometriosis. Int J Cancer 120:1372–1375PubMedCrossRefGoogle Scholar
  22. 22.
    Matalliotakis IM, Cakmak H, Mahutte N, Goumenou AG, Koumantakis G, Arici A (2008) The familial risk of breast cancer in women with endometriosis from Yale series. Surg Oncol 17:289–293PubMedCrossRefGoogle Scholar
  23. 23.
    Matsuo K, Alonsozana EL, Eno ML, Rosenshein NB, Im DD (2009) Primary peritoneal clear cell adenocarcinoma arising in previous abdominal scar for endometriosis surgery. Arch Gynecol Obstet 280:637–641PubMedCrossRefGoogle Scholar
  24. 24.
    Kobayashi S, Sasaki M, Goto T et al (2010) Endometrioid adenocarcinoma arising from endometriosis of the rectosigmoid. Dig Endosc 22:59–63PubMedCrossRefGoogle Scholar
  25. 25.
    Staats PN, Clement PB, Young RH (2007) Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases. Am J Surg Pathol 31:1490–1501PubMedCrossRefGoogle Scholar
  26. 26.
    Peiretti M, Zakashansky K, Melis GB, Mais V (2008) Unusual case of adenocarcinoma arising in endometriosis mimicking colorectal cancer in a young woman with a Müllerian anomaly. Fertil Steril 90:199.e13–5PubMedCrossRefGoogle Scholar
  27. 27.
    Swiersz LM (2002) Role of endometriosis in cancer and tumor development. Ann NY Acad Sci 955:281–292PubMedCrossRefGoogle Scholar
  28. 28.
    Boruban MC, Jaishuen A, Sirisabya N et al (2008) Ovarian endometriosis associated with carcinoma and sarcoma: case report. Eur J Gynaecol Oncol 29:393–396PubMedGoogle Scholar
  29. 29.
    Oppelt P, Renner SP, Strick R et al (2010) Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions. Fertil Steril 93:1778–1786PubMedCrossRefGoogle Scholar
  30. 30.
    Ali-Fehmi R, Khalifeh I, Bandyopadhyay S et al (2006) Patterns of loss of heterozygosity at 10q23.3 and microsatellite instability in endometriosis, atypical endometriosis, and ovarian carcinoma arising in association with endometriosis. Int J Gynecol Pathol 25:223–229PubMedCrossRefGoogle Scholar
  31. 31.
    Borghese B, Mondon F, Noël JC et al (2008) Gene expression profile for ectopic versus eutopic endometrium provides new insights into endometriosis oncogenic potential. Mol Endocrinol 22:2557–2562PubMedCrossRefGoogle Scholar
  32. 32.
    Mandai M, Yamaguchi K, Matsumura N, Baba T, Konishi I (2009) Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management. Int J Clin Oncol 14:383–391PubMedCrossRefGoogle Scholar
  33. 33.
    Götte M, Wolf M, Staebler A et al (2008) Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. J Pathol 215:317–329PubMedCrossRefGoogle Scholar
  34. 34.
    Guo SW (2009) Epigenetics of endometriosis. Mol Hum Reprod 15:587–607PubMedCrossRefGoogle Scholar
  35. 35.
    Kondi-Paphitis A, Smyrniotis B, Liapis A, Kontoyanni A, Deligeorgi H (1998) Stromal sarcoma arising on endometriosis. A clinicopathological and immunohistochemical study of 4 cases. Eur J Gynaecol Oncol 19:588–590PubMedGoogle Scholar
  36. 36.
    Kobayashi H, Yamada Y, Kanayama S et al (2009) The role of iron in the pathogenesis of endometriosis. Gynecol Endocrinol 25:39–52PubMedCrossRefGoogle Scholar
  37. 37.
    Yap OW, Bhat G, Liu L, Tollefsbol TO (2009) Epigenetic modifications of the estrogen receptor β gene in epithelial ovarian cancer cells. Anticancer Res 29:139–144PubMedGoogle Scholar
  38. 38.
    Karita M, Yamashita Y, Hayashi A, et al. (2011) Does advanced-stage endometriosis affect the gene expression of estrogen and progesterone receptors in granulosa cells? Fertil Steril 95:889–894PubMedCrossRefGoogle Scholar
  39. 39.
    Bulun SE, Cheng YH, Yin P et al (2006) Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol 248:94–103PubMedCrossRefGoogle Scholar
  40. 40.
    Govindan S, Ahmad SN, Vedicherla B et al (2007) Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer. Cancer Biomark 3:73–78PubMedGoogle Scholar
  41. 41.
    Grammatikakis I, Zervoudis S, Evangelinakis N, Tziortzioti V (2010) Endometrium and ovarian cancer synchronous to endometriosis—a retrospective study of our experience of 7 years. J Med Life 3:76–79PubMedGoogle Scholar
  42. 42.
    Kondi-Pafiti A, Grapsa D, Liapis A, Papadias K, Kairi-Vassilatou E, Hasiakos D (2008) Synchronous ovarian and endometrial carcinoma: a strong link to endometriosis? Eur J Gynaecol Oncol 29:256–259PubMedGoogle Scholar
  43. 43.
    Vaissière T, Sawan C, Herceg Z (2008) Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res 659:40–48PubMedCrossRefGoogle Scholar
  44. 44.
    Takemura Y, Osuga Y, Harada M et al (2005) Serum adiponectin concentrations are decreased in women with endometriosis. Hum Reprod 20:3510–3513PubMedCrossRefGoogle Scholar
  45. 45.
    Beebe-Dimmer JL, Zuhlke KA, Ray AM, Lange EM, Cooney KA (2010) Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Prostatic Dis 13:362–368PubMedCrossRefGoogle Scholar
  46. 46.
    Massuger L, Roelofsen T, Ham M, Bulten J (2010) The origin of serous ovarian cancer may be found in the uterus: a novel hypothesis. Med Hypotheses 74:859–861PubMedCrossRefGoogle Scholar
  47. 47.
    Depalo R, Cavallini A, Lorusso F et al (2009) Apoptosis in normal ovaries of women with and without endometriosis. Reprod Biomed Online 19:808–815PubMedCrossRefGoogle Scholar
  48. 48.
    Hirabayashi K, Yasuda M, Kajiwara H et al (2009) Clear cell adenocarcinoma arising from adenomyosis. Int J Gynecol Pathol 28:262–266PubMedCrossRefGoogle Scholar
  49. 49.
    Mhawech P, Kinkel K, Vlastos G, Pelte MF (2002) Ovarian carcinomas in endometriosis: an immunohistochemical and comparative genomic hybridization study. Int J Gynecol Pathol 21:401–406PubMedCrossRefGoogle Scholar
  50. 50.
    Barros SP, Offenbacher S (2009) Epigenetics: connecting environment and genotype to phenotype and disease. J Dent Res 88:400–408PubMedCrossRefGoogle Scholar
  51. 51.
    Van Patten K, Parkash V, Jain D (2010) Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy. Mod Pathol 23:38–44PubMedCrossRefGoogle Scholar
  52. 52.
    Shaco-Levy R, Sharabi S, Benharroch D, Piura B, Sion-Vardy N (2008) Matrix metalloproteinases 2 and 9, E-cadherin, and beta-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium. Eur J Obstet Gynecol Reprod Biol 139:226–232PubMedCrossRefGoogle Scholar
  53. 53.
    Nyiraneza C, Marbaix E, Smets M, Galant C, Sempoux C, Dahan K (2010) High risk for neoplastic transformation of endometriosis in a carrier of Lynch syndrome. Fam Cancer 9:383–387PubMedCrossRefGoogle Scholar
  54. 54.
    Kobayashi H, Kajiwara H, Kanayama S et al (2009) Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). Oncol Rep 22:233–240PubMedCrossRefGoogle Scholar
  55. 55.
    Konishi I (2009) Ovarian cancer in endometriosis. Int J Clin Oncol 14:377PubMedCrossRefGoogle Scholar
  56. 56.
    Keita M, Bessette P, Pelmus M, Ainmelk Y, Aris A (2010) Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes. J Ovarian Res 3:3PubMedCrossRefGoogle Scholar
  57. 57.
    Wilson AG (2008) Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 79:1514–1519PubMedCrossRefGoogle Scholar
  58. 58.
    Mach P, Blecharz P, Basta P et al (2010) Differences in the soluble HLA-G blood serum concentration levels in patients with ovarian cancer and ovarian and deep endometriosis. Am J Reprod Immunol 63:387–395PubMedCrossRefGoogle Scholar
  59. 59.
    Gemmill JA, Stratton P, Cleary SD, Ballweg ML, Sinaii N (2010) Cancers, infections, and endocrine diseases in women with endometriosis. Fertil Steril 94:1627–1631PubMedCrossRefGoogle Scholar
  60. 60.
    Khan KN, Kitajima M, Hiraki K et al (2008) Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol 60:383–404PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, School of MedicineUniversity of Ondokuz MayisSamsunTurkey
  2. 2.Bahcelievler mah, Abdülhakhamid CadSamsunTurkey

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