Archives of Gynecology and Obstetrics

, Volume 284, Issue 5, pp 1271–1276 | Cite as

Metabolic syndrome is an independent risk factor for breast cancer

  • Lakymê Ângelo Mangueira Porto
  • Karla Jamille Bezerra Lora
  • Juliana Coutinho Miranda Soares
  • Laura Olinda Bregieiro Fernandes Costa
Gynecologic Oncology

Abstract

Objective

This study was aimed to assess the prevalence of metabolic syndrome in patients with breast cancer and the independent effect of metabolic syndrome on breast cancer risk.

Methods

Eighty-one women aged 40–80 years with breast cancer and 81 controls of similar age were screened for metabolic syndrome prevalence and breast cancer risk factors, including age at diagnosis, age at menarche, reproductive status, live births, breastfeeding, family history of breast cancer, physical activity, cigarette smoking, body mass index, and metabolic syndrome parameters. Each variable was first assessed for baseline comparisons using the univariate model, and significant variables were then added to the multivariate conditional logistic regression model.

Results

Prevalence of metabolic syndrome was 59.2% in breast cancer patients, and 37% in the control group (p < 0.005). A positive and independent association was observed between metabolic syndrome and breast cancer risk (odds ratio = 2.49; 95% confidence interval 1.17–5.30).

Conclusion

Metabolic syndrome is more prevalent in breast cancer patients and is an independent risk factor for breast cancer.

Keywords

Metabolic syndrome Breast cancer Risk factor Hyperinsulinemia Insulin resistance 

References

  1. 1.
    Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A et al (2005) Cancer statistics, 2005. CA Cancer J Clin 55(1):10–30PubMedCrossRefGoogle Scholar
  2. 2.
    Cust AE, Stocks T, Lukanova A, Lundin E, Hallmans G, Kaaks R et al (2009) The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study. Breast Cancer Res Treat 113(3):567–576PubMedCrossRefGoogle Scholar
  3. 3.
    Rose DP, Haffner SM, Baillargeon J (2007) Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women. Endocr Rev 28(7):763–777PubMedCrossRefGoogle Scholar
  4. 4.
    Connolly BS, Barnett C, Vogt KN, Li T, Stone J, Boyd NF (2002) A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer. Nutr Cancer 44(2):127–138PubMedCrossRefGoogle Scholar
  5. 5.
    Harvie M, Hooper L, Howell AH (2003) Central obesity and breast cancer risk: a systematic review. Obes Rev 4(3):157–173PubMedCrossRefGoogle Scholar
  6. 6.
    Lawlor DA, Smith GD, Ebramim S (2004) Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women’s Heart and Health Study. Cancer Causes Control 15(3):267–275PubMedCrossRefGoogle Scholar
  7. 7.
    Strange KS, Wilkinson D, Edin G, Emerman JT (2004) Mitogenic properties of insulin-like growth factors I and II, insulin-like growth factor binding protein-3 and epidermal growth factor on human breast stromal cells in primary culture. Breast Cancer Res Treat 84(2):77–84PubMedCrossRefGoogle Scholar
  8. 8.
    Sinagra D, Amato C, Scarpita AM, Brigandi M, Amato M, Saura G et al (2002) Metabolic syndrome and breast cancer risk. Eur Rev Med Pharmacol Sci 6(2–3):55–59PubMedGoogle Scholar
  9. 9.
    Campbell CY, Nasir K, Carvalho JA, Blumenthal RS, Santos RD (2008) The metabolic syndrome adds incremental value to the Framingham risk score in identifying asymptomatic individuals with higher degrees of inflammation. J Cardiometab Syndr 3(1):7–11PubMedCrossRefGoogle Scholar
  10. 10.
    Guastamacchia E, Resta F, Triggiani V, Liso A, Licchelli B, Ghiyasaldin S et al (2004) Evidence for a putative relationship between type 2 diabetes and neoplasia with particular reference to breast cancer: role of hormones, growth factors and specific receptors. Curr Drug Targets Immune Endocr Metabol Disord 4(1):59–66PubMedCrossRefGoogle Scholar
  11. 11.
    Pasanisi P, Berrino F, De Petris M, Venturelli E, Mastroiani A, Panico S (2006) Metabolic syndrome as a prognostic factor for breast cancer recurrences. Int J Cancer 119(1):236–238PubMedCrossRefGoogle Scholar
  12. 12.
    Bener A, Zirie M, Musallam M, Khader YS, Al-Hamaq A (2009) Prevalence of metabolic syndrome according to Adult Treatment Panel III and International Diabetes Federation criteria: a population-based study. Metab Syndr Relat Disord 7(3):221–229PubMedCrossRefGoogle Scholar
  13. 13.
    Third Report of The National Cholesterol Education Program (NCEP) (2002) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106(25):3143–3421Google Scholar
  14. 14.
    Russo A, Autelitano M, Bisanti L (2008) Metabolic syndrome and cancer risk. Eur J Cancer 44(2):293–297PubMedCrossRefGoogle Scholar
  15. 15.
    Capasso I, Esposito E, Pentimalli F, Crispo A, Montella M, Grimaldi M et al. (2010) Metabolic syndrome affects breast-cancer risk in postmenopausal women: National Cancer Institute of Naples experience. Cancer Biol Ther 10(12). [Epub ahead of print]Google Scholar
  16. 16.
    Agnoli C, Berrino F, Abagnato CA, Muti P, Panico S, Crosignani P, Krogh V (2010) Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: a nested case- control study. Nutr Metab Cardiovasc Dis 20(1):41–48PubMedCrossRefGoogle Scholar
  17. 17.
    Park KG, Park KS, Kim MJ, Kim HS, Suh YS, Ahn JD et al (2004) Relationship between serum adiponectin and leptin concentrations and body fat distribution. Diabetes Res Clin Pract 63(2):135–142PubMedCrossRefGoogle Scholar
  18. 18.
    Bradley LM, Gierthy JF, Pentecost BT (2008) Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the MCF-7 human breast cancer cell line. J Steroid Biochem Mol Biol 109(1–2):185–196PubMedCrossRefGoogle Scholar
  19. 19.
    Vadgama JV, Scuric Z, Chakrabarti R, Marzo E, Shen D, Wu Y (2006) Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Int J Mol Med 18(1):129–139PubMedGoogle Scholar
  20. 20.
    Dieudonne MN, Bussiere M, Dos Santos E, Leneveu MC, Giudicelli Y, Pecquery R (2006) Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun 345(1):271–279PubMedCrossRefGoogle Scholar
  21. 21.
    Furberg AS, Jasienska G, Bjurstam N, Torjesen PA, Emaus A, Lipson SF et al (2005) Metabolic and hormonal profiles: HDL cholesterol as a plausible biomarker of breast cancer risk. The Norwegian EBBA Study. Cancer Epidemiol Biomarkers Prev 14(1):33–40PubMedGoogle Scholar
  22. 22.
    Krebs EE, Taylor BC, Cauley JA, Stone KL, Bowman PJ, Ensrud KE (2006) Measures of adiposity and risk of breast cancer in older postmenopausal women. J Am Geriatr Soc 54(1):63–69PubMedCrossRefGoogle Scholar
  23. 23.
    Ursin G, Longnecker MP, Haile RW, Greenland S (1995) A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology 6(2):137–141PubMedCrossRefGoogle Scholar
  24. 24.
    Neilson HK, Friedenreich CM, Brockton NT, Millikan RC (2009) Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev 18(1):11–27PubMedCrossRefGoogle Scholar
  25. 25.
    Braithwaite D, Tammemagi CM, Moore DH, Ozanne EM, Hiatt RA, Belkora J et al (2009) Hypertension is an independent predictor of survival disparity between African-American and white breast cancer patients. Int J Cancer 124(5):1213–1219PubMedCrossRefGoogle Scholar
  26. 26.
    Lindgren AM, Nissinen AM, Tuomilehto JO, Pukkala E (2005) Cancer pattern among hypertensive patients in North Karelia, Finland. J Hum Hypertens 19(5):373–379PubMedCrossRefGoogle Scholar
  27. 27.
    Cheng Z, Vapaatalo H, Mervaala E (2005) Angiotensin II and vascular inflammation. Med Sci Monit 11(6):RA194–RA205PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Lakymê Ângelo Mangueira Porto
    • 1
  • Karla Jamille Bezerra Lora
    • 1
  • Juliana Coutinho Miranda Soares
    • 1
  • Laura Olinda Bregieiro Fernandes Costa
    • 1
    • 2
  1. 1.Division of Gynecological Endocrinology and Human Reproduction, Department of Obstetrics and Gynaecology, Medical SchoolUniversity of PernambucoRecifeBrazil
  2. 2.RecifeBrazil

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