Ovarian morphology and endocrine function in polycystic ovary syndrome
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To assess the relationship between ovarian morphology, hormonal levels and anthropometrical characteristics in a group of patients with polycystic ovary syndrome (PCOS).
This prospective, cross-sectional study included 82 patients with diagnosis of PCOS and 21 women with regular menstrual cycles without hyperandrogenism. They were submitted to endovaginal pelvic ultrasound. Anthropometric measures and hormonal levels of LH, FSH, insulin, total testosterone (T), free T, dehydroepiandrosterone and dehydroepiandrosterone sulfate were evaluated. The morphology of polycystic ovary (PCO) was considered when 12 or more follicles, less than 10 mm in diameter, in one or both ovaries, were observed. PCOS patients were divided into two groups: with PCO (n = 51) and without PCO (n = 31).
In 51 out of 82 (62%) patients with PCOS, an image of PCO was observed. PCOS Patients with PCO showed a significantly greater body mass index and hip perimeter than PCOS patients without PCO. Higher levels of total T and free T were found in PCOS patients with PCO compared to those without PCO.
PCOS patients with PCO on ultrasound present greater hyperandrogenism and obesity than PCOS patients without PCO. The presence of PCO appears to indicate a major clinical alteration of PCOS.
KeywordsPolycystic ovary syndrome Hyperandrogenism Ovarian morphology
The authors thank Jaime Rodriguez and Maria G. Torres for their technical help and dedication to this study. This study was supported in part by the following research grants: 38371-M from CONACYT, and 2006/1A/I/019 from IMSS, Mexico.
- 5.Zawadski JK, Dunaif A (1992) Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine F, Merriam GR (eds) Polycystic ovary syndrome. Blackwell, Boston, pp 377–384Google Scholar
- 6.The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Hum Reprod19:41–47Google Scholar
- 7.Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W et al (2006) Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 91:4237–4245PubMedCrossRefGoogle Scholar
- 12.WHO Expert Committee (1995) Physical status: the use and interpretation of anthropometry. WHO Tec Rep Ser No. 854. Geneva, WHO, 1995Google Scholar
- 14.Treloar AE, Boynton RE, Behn BG, Brown BW (1967) Variation of the human menstrual cycle trough reproductive life. Int J Fert 12:77–126Google Scholar
- 15.Dewailly D, Catteau-Jonard S, Poncelet E (2010) Which morphological investigations and how to interpret them to make the diagnosis of PCOS? Ann Endocrinol (Paris) 71:183–188Google Scholar
- 24.Welt CK, Gudmundsson JA, Arason G, Adams J, Palsdottir H, Gudlaugsdottir G et al (2006) Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features. J Clin Endocrinol Metab 91:4842–4848PubMedCrossRefGoogle Scholar