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Archives of Gynecology and Obstetrics

, Volume 284, Issue 5, pp 1099–1104 | Cite as

Gestational diabetes: a strong independent risk factor for severe neonatal respiratory failure after 34 weeks

  • Pauline Vignoles
  • Catherine Gire
  • Julien Mancini
  • Florence Bretelle
  • Léon Boubli
  • Eustase Janky
  • Xavier CarcopinoEmail author
Materno-fetal Medicine

Abstract

Purpose

To evaluate if gestational diabetes (GD) exposes neonates delivered after 34 weeks to an increased risk of severe neonatal respiratory failure (NRF).

Methods

Data from 3,237 women who delivered after 34 weeks with systematic screening for GD were analyzed. Diagnosis of severe NRF required the association of clinical and radiological criteria with a minimum of 24 h of ventilation and admission to neonatal intensive care unit.

Results

A total of 166 (5.1%) cases of GD were identified. Severe NRF was diagnosed in 7 (4.21%) cases among women with GD as compared to 13 (0.42%) in others (p < 0.001). The rate of severe NRF was also significantly higher in cases of premature delivery (p < 0.001), fetal growth retardation (p < 0.001), and cesarean section (p = 0.005). After adjustment for these variables, GD was identified as an independent risk factor for NRF (AOR 11.55, 95% CI 3.9–33.9, p < 0.001). Two other risk factors were also identified: late preterm delivery (AOR 6.13, 95% CI 1.8–21.2, p = 0.004); and hypotrophy (AOR 9.16, 95% CI 2.7–30.5, p < 0.001).

Conclusions

GD is an independent risk factor for severe NRF after 34 weeks. Neonates from such pregnancies should be monitored carefully.

Keywords

Diabetes mellitus Gestational diabetes Neonatal respiratory failure Ventilation Late preterm delivery 

Notes

Acknowledgments

Funding source none.

Conflict of interest

All authors have no conflict of interest to declare.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Pauline Vignoles
    • 1
    • 2
  • Catherine Gire
    • 4
  • Julien Mancini
    • 3
  • Florence Bretelle
    • 2
  • Léon Boubli
    • 2
  • Eustase Janky
    • 1
  • Xavier Carcopino
    • 2
    Email author
  1. 1.Service de Gynécologie ObstétriqueHôpital de Pointe-à Pitre AbymesPointe à Pitre Cedex, GuadeloupeFrance
  2. 2.Service de Gynécologie ObstétriqueHôpital Nord, Chemin des BourrelyMarseilleFrance
  3. 3.Service Santé PubliqueHôpital de la TimoneMarseille Cedex 5France
  4. 4.Service de PédiatrieHôpital Nord, Chemin des BourrelyMarseilleFrance

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