Archives of Gynecology and Obstetrics

, Volume 284, Issue 4, pp 837–841 | Cite as

The association between inherited thrombophilias and pregnancy-related hypertension recurrence

  • Inanc MendilciogluEmail author
  • Turker Bilgen
  • Yunus Arikan
  • Ibrahim Keser
  • Mehmet Simsek
  • Aysen Timuragaoglu
Materno-fetal Medicine



The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence.


In this case–control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method.


Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6–1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations.


Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence.


Factor V Leiden Inherited thrombophilia Preeclampsia Pregnancy-related hypertension Prothrombin G20210A 



This study was supported by the Research Projects Management Unit, Akdeniz University.

Conflict of interest



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Inanc Mendilcioglu
    • 1
    Email author
  • Turker Bilgen
    • 2
  • Yunus Arikan
    • 2
  • Ibrahim Keser
    • 2
  • Mehmet Simsek
    • 1
  • Aysen Timuragaoglu
    • 3
  1. 1.Department of Obstetrics and Gynecology, School of MedicineAkdeniz UniversityAntalyaTurkey
  2. 2.Department of Medical Genetics, School of MedicineAkdeniz UniversityAntalyaTurkey
  3. 3.Department of Hematology, School of MedicineAkdeniz UniversityAntalyaTurkey

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