The association between inherited thrombophilias and pregnancy-related hypertension recurrence
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The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence.
In this case–control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method.
Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6–1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations.
Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence.
KeywordsFactor V Leiden Inherited thrombophilia Preeclampsia Pregnancy-related hypertension Prothrombin G20210A
This study was supported by the Research Projects Management Unit, Akdeniz University.
Conflict of interest
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