Significance of PTPRZ1 and CIN85 expression in cervical carcinoma
- 171 Downloads
To investigate PTPRZ1 and CIN85 expression and their significance in cervical carcinoma.
The expression of PTPRZ1 and CIN85 was detected by immunohistochemistry and the association between PTPRZ1 and CIN85 expression and clinical pathological variables were analyzed.
The expression of PTPRZ1 and CIN85 were significantly higher in cervical carcinoma than those in normal cervical epithelium. CIN85 expression was significantly higher in patients with deeper cervical invasion when compared with that with superficial invasion, while PTPRZ1 expression was significantly higher in patients with smaller tumor size (≤2 cm) than that with larger size (>2 cm). The expression of PTPRZ1 and CIN85 were higher in squamous cell carcinoma than those in adenocarcinoma.
There exist increased PTPRZ1 and CIN85 expression in cervical carcinoma and they are probably associated with tumor growth or invasion. PTPRZ1 and CIN85 expression were higher in squamous cell carcinoma than those in adenocarcinoma.
KeywordsGynae-oncology PTPRZ1 CIN85 Cervical carcinoma
This work was supported by the Scientific Research Foundation of Education Department of Zhejiang Province, China (Y200908905), Scientific Research Foundation of Ministry of Health, China (wkj2007-2-014) and the Nature Science Foundation of China (30872752).
Conflict of interest
We declare that we have no conflict of interest.
- 13.Petereit DG, Eifel PJ, Thomas GM (2007) Cervical cancer. In: Gunderson LL, Tepper JE (eds) Clinical radiation oncology, 2nd edn. Churchill Livingstone, Philadelphia, pp 1323–1357Google Scholar
- 14.Gadducci A, Teti G, Barsotti C, Tana R, Fanucchi A, Orlandini C et al (2010) Clinicopathological variables predictive of clinical outcome in patients with FIGO stage Ib2-IIb cervical cancer treated with cisplatin-based neoadjuvant chemotherapy followed by radical hysterectomy. Anticancer Res 30(1):201–208PubMedGoogle Scholar
- 15.Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M et al (2000) Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci USA 97(6):2603–2608PubMedCrossRefGoogle Scholar