Archives of Gynecology and Obstetrics

, Volume 284, Issue 1, pp 105–110

A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis

  • Saeed Alborzi
  • Bahareh Hamedi
  • Azizeh Omidvar
  • Sedigheh Dehbashi
  • Soroosh Alborzi
  • Mehrnoosh Alborzi
General Gynecology



To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptorelin) versus case control on the pregnancy rate and recurrence of symptoms and signs in patients with endometriosis.


In a prospective randomized clinical trial, after treatment of 144 infertile women in their reproductive age by laparoscopy (whose endometriosis was confirmed by prior laparoscopy), they were divided into 3 groups: group 1 (47 cases) who received letrozole for 2 months, group 2 (40 patients) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication. We followed up each group at least for 12 months after their restoration of regular cycle.


Pregnancy rate was 23.4% in group 1, 27.5% in group 2, and 28.1% in group 3. The results did not show significant differences among the 3 groups. Recurrence rate of endometriosis was 6.4% in group 1, 5% group 2 and 5.3% in group 3, which was not statistically significantly different as well.


Pregnancy rate and endometriosis recurrence rate are comparable among the 3 groups.


Letrozole Triptorelin Endometriosis Laparoscopy 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Saeed Alborzi
    • 1
  • Bahareh Hamedi
    • 1
  • Azizeh Omidvar
    • 1
  • Sedigheh Dehbashi
    • 1
  • Soroosh Alborzi
    • 1
  • Mehrnoosh Alborzi
    • 1
  1. 1.Division of Infertility and Endoscopic Surgery, Department of Obstetrics and Gynecology, School of MedicineShiraz University of Medical SciencesShirazIran

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