Archives of Gynecology and Obstetrics

, Volume 283, Issue 5, pp 1145–1148

Aggressive angiomyxoma of vulva and vagina: a series of three cases and review of literature

  • Krishna Dahiya
  • Shaveta Jain
  • Nirmala Duhan
  • Smiti Nanda
  • Parveen Kundu
Gynecologic Oncology

Abstract

Background

Aggressive angiomyxoma is a rare locally aggressive mesenchymal tumor of unknown etiology usually affecting the vulva, perianal region, buttocks or pelvis of reproductive age women.

Material

A series of three cases, one each of vaginal, vulval and labial angiomyxoma is being presented. The etiology, presentation, diagnosis and management of this rare genital tumor are outlined.

Conclusion

Angiomyxoma of vulva and vagina refers to a rare disease; diagnosis is not at all clinical, thus, cases presenting as bartholin cyst, benign vulval lesions and vaginal wall cysts should have complete radiological work up before excision, as pre-diagnosis can change the treatment modality and prognosis of patient.

Keywords

Angiomyxoma Vagina Vulva 

References

  1. 1.
    Steeper TA, Rosai J (1983) Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol 7:463–475PubMedCrossRefGoogle Scholar
  2. 2.
    Salman MC, Kuzey GM, Dogan NU, Yuce K (2009) Aggressive angiomyxoma of vulva recurring 8 years after initial diagnosis. Arch Gynecol Obstet 280:485–487PubMedCrossRefGoogle Scholar
  3. 3.
    Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM (1996) Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer 78:79–90PubMedCrossRefGoogle Scholar
  4. 4.
    Smith HO, Worrell RV, Smith AY, Dorin MH, Rosenberg RD, Bartow SA (1991) Aggressive angiomyxoma of the female pelvis and perineum: review of the literature. Gynecol Oncol 42:79–85PubMedCrossRefGoogle Scholar
  5. 5.
    Nucci MR, Fletchr CD (2000) Vulvovaginal soft tissue tumors: update and review. Histopathology 36:97–108PubMedCrossRefGoogle Scholar
  6. 6.
    Blandamura S, Cruz J, Faure Vergara L, Machado Puerto I, Ninfo V (2003) Aggressive angiomyxoma: a second case of metastasis with patient’s death. Hum Pathol 34:1072–1074PubMedCrossRefGoogle Scholar
  7. 7.
    McCluggage WG, Patterson A, Maxwell P (2000) Aggressive angiomyxoma of pelvic parts exhibits estrogen and progesterone receptor positivity. J Clin Pathol 53:603–605PubMedCrossRefGoogle Scholar
  8. 8.
    Dierickx I, Deraedt K, Poppe W, Verguts J (2008) Aggressive angiomyxoma of the vulva: a case report and review of literature. Arch Gynecol Obstet 277(6):483–487PubMedCrossRefGoogle Scholar
  9. 9.
    Outwater EK, Marchetto BE, Wagner BJ, Siegelman ES (1999) Aggressive angiomyxoma: findings on CT and MR imaging. AJR Am J Roentgenol 172:435–438PubMedGoogle Scholar
  10. 10.
    Wiser A, Korach J, Gotlieb WH, Fridman E, Apter S, Ben-Baruch G (2006) Importance of accurate preoperative diagnosis in the management of aggressive angiomyxoma: report of three cases and review of the literature. Abdom Imaging 31:383–386PubMedCrossRefGoogle Scholar
  11. 11.
    Han-Geurts IJ, van Geel AN, van Doorn L, den Bakker M, Eggermont AM, Verhoef C (2006) Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery. Eur J Surg Oncol 32:1217–1221PubMedCrossRefGoogle Scholar
  12. 12.
    Simo M, Zapata C, Esquis J, Domingo J (1992) Aggressive angiomyxoma of the female pelvis and perineum. Report of two cases and review of the literature. Br J Obstet Gynaecol 99(11):925–927PubMedCrossRefGoogle Scholar
  13. 13.
    Chan YM, Hon E, Ngai SW, Ng TY, Wong LC, Chan IM (2000) Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand 79:216–220PubMedCrossRefGoogle Scholar
  14. 14.
    Bagga R, Keepanasseril A, Suri V, Nijhawan R (2007) Aggressive angiomyxoma of the vulva in pregnancy: a case report and review of management options. MedGenMed 9(1):16–20PubMedGoogle Scholar
  15. 15.
    Fishman A, Otey LP, Poindexter AN, Shannon RL, Gritanner RE, Kaplan Al (1995) Aggressive angiomyxoma of the pelvis and perineum. A case report. J Reprod Med 40:665–669PubMedGoogle Scholar
  16. 16.
    Agarwal N, Lal S, Kriplani A (2007) Estrogen-dependent recurrent aggressive angiomyxoma of the vulva: a surgical enigma. J Gynecol Surg 23(1):37–40CrossRefGoogle Scholar
  17. 17.
    Poirier M, Fraser R, Meterissian S (2003) Aggressive angiomyxoma of the pelvis: response to luteinizing hormone-releasing hormone agonist. J Clin Oncol 21:3535–3536PubMedCrossRefGoogle Scholar
  18. 18.
    Fine BA, Munoz AK, Litz CE, Gershenson DM (2001) Primary medical management of recurrent aggressive angiomyxoma of the vulva with gonadotropin releasing hormone agonist. Gynecol Oncol 81:120–122PubMedCrossRefGoogle Scholar
  19. 19.
    Giles DL, Liu PT, Lidner TK, Magtibay PM (2008) Treatment of aggressive angiomyxoma with aromatase inhibitor prior to surgical resection. Int J Gynecol Cancer 18(2):375–379PubMedCrossRefGoogle Scholar
  20. 20.
    Nyam DC, Pemberton JH (1998) Large aggressive angiomyxoma of the perineum and pelvis: an alternative approach. Dis Colon Rectum 41:514–516PubMedCrossRefGoogle Scholar
  21. 21.
    Siassi RM, Papadopoulos T, Matzel KE (1999) Metastasizing aggressive angiomyxoma. N Eng J Med 2:1772CrossRefGoogle Scholar
  22. 22.
    Suleiman M, Duc C, Ritz S, Bieri S (2008) Pelvic excision of large aggressive angiomyxoma in a woman: irradiation for recurrent disease. Int J Gynecol Cancer 16(S1):356–360CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Krishna Dahiya
    • 1
  • Shaveta Jain
    • 1
  • Nirmala Duhan
    • 1
  • Smiti Nanda
    • 1
  • Parveen Kundu
    • 2
  1. 1.Department of Obstetrics and GynecologyPt.BDS, PGIMSRohtakIndia
  2. 2.Department of PathologyPt.BDS, PGIMSRohtakIndia

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