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Archives of Gynecology and Obstetrics

, Volume 283, Issue 5, pp 1045–1051 | Cite as

Effects of estradiol–drospirenone hormone treatment on carotid artery intima-media thickness and vertigo/dizziness in postmenopausal women

  • Hakan CoksuerEmail author
  • Mustafa Koplay
  • Fatih Oghan
  • Cengiz Coksuer
  • Nadi Keskin
  • Olcay Ozveren
General Gynecology

Abstract

Aim

To investigate the effects of Angeliq on hormonal, metabolic, biochemical and cardiovascular profile, carotid intima-media thickness (CIMT) and vertigo/dizziness symptoms in postmenopausal women.

Methods

Angeliq is a drug used for hormone replacement therapy that composed of drospirenone 2 mg and estradiol 1 mg. Thirty-two postmenopausal women were recruited for the study. All women were evaluated using personal interview, medical examination and carotid artery ultrasound. They were questioned specifically about vertigo/dizziness experienced. Participants were randomly submitted to oral daily treatment with Angeliq. The duration of the study was 6 months and the participants were studied in basal condition and after 6 months of the therapy.

Results

Follicle-stimulating hormone was significantly higher and estradiol was significantly lower in before therapy (BT) than in after therapy (AT) (p < 0.001). No differences in fasting glucose, CRP and WBC values, and lipid–lipoprotein profile were detected between the groups. The systolic and diastolic blood pressures and heart rate were also significantly higher in BT than in AT (p < 0.05). A significant (p < 0.001) difference in CIMT (0.51 ± 0.04 vs. 0.49 ± 0.03 mm) was found between BT and AT. Seven of 32 patients (22%) had vertigo/dizziness symptoms before treatment. After 6 months, none of the patients showed complaints of vertigo/dizziness.

Conclusions

Oral daily treatment with Angeliq reduces CIMT and climacteric complaints including vertigo/dizziness in postmenopausal women. They may relate to anti-androgenic and anti-mineralocorticoid effects of Angeliq, respectively.

Keywords

Cardiovascular disease Carotid intima-media thickness Drospirenone Menopause Vertigo/dizziness 

Abbreviations

AT

After therapy

BT

Before therapy

BMI

Body mass index

CHD

Coronary heart disease

CIMT

Carotid intima-media thickness

CRP

C-reactive protein

DBP

Diastolic blood pressure

DRSP/E2

Drospirenone–estradiol

E2

Estradiol

FSH

Follicle-stimulating hormone

HRT

Hormone replacement therapy

HDL

High-density lipoprotein

PW

Postmenopausal women

SBP

Systolic blood pressure

TC

Total cholesterol

TG

Triglycerides

LDL

Low-density lipoprotein

WBC

White blood cells count

Notes

Conflict of interest statement

There is no conflict of interest between the authors.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hakan Coksuer
    • 1
    Email author
  • Mustafa Koplay
    • 2
  • Fatih Oghan
    • 3
  • Cengiz Coksuer
    • 5
  • Nadi Keskin
    • 1
  • Olcay Ozveren
    • 4
  1. 1.Department of Obstetrics and Gynecology, Faculty of Medicine, School of MedicineDumlupınar UniversityKutahyaTurkey
  2. 2.Department of Radiology, School of MedicineDumlupinar UniversityKutahyaTurkey
  3. 3.Department of Otorhinolaryngology, School of MedicineDumlupinar UniversityKutahyaTurkey
  4. 4.Department of Cardiology, School of MedicineDumlupinar UniversityKutahyaTurkey
  5. 5.Cizre State HospitalKutahyaTurkey

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