Comments on the letter “Fertility preservation and GnRHa for chemotherapy: debate”
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Thank you very much for the critical comments. Any critical comment on the use of GnRH analogs (GnRHa) to protect fertility during chemotherapy is of great value in further discussions of the controversial data and the controversial attitudes of endocrinologists and ocologists.
We fully agree with the authors of the letter that several studies support the efficacy of GnRHa to protect the ovaries, which we have also demonstrated in a review summarizing nine studies on the use of GnRHa . We also agree with the authors that the efficacy of other fertility preserving techniques such as cryopreservation and transplantation of ovarian tissue need further evaluation and that their safety has still not absolutely been proven, as stated in our recent review about cryopreservation of ovarian tissue . Finally, we are fully aware that GnRHa provide several additional advantages during chemotherapy such as reducing the risk of thrombocytopenia-associated menorrhagia.
However, we do not agree...
KeywordsBreast Cancer Patient Ovarian Tissue Ovarian Stimulation Fertility Preservation GnRH Analog
Conflict of interest statement
- 2.von Wolff M, Donnez J, Hovatta O, Keros V, Maltaris T, Montag M, Salle B, Sonmezer M, Andersen CY (2009) Cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy—a technique in its infancy but already successful in fertility preservation. Eur J Cancer 45:1547–1553CrossRefGoogle Scholar
- 5.Ismail-Khan R, Minton S, Cox C et al (2008) Preservation of ovarian function in young women treated with neoadjuvant chemotherapy for breast cancer: a randomized trial using GnRH agonist (triptoreline) during chemotherapy. J Clin Oncol 26(Suppl 1):12s Abstract 524Google Scholar
- 7.Behringer K, Wildt L, Mueller H, Mattle V, Ganitis P, van den Hoonaard B, Ott HW, Hofer S, Pluetschow A, Diehl V, Engert A, Borchmann P, on behalf of the German Hodgkin Study Group (2010) No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group. Ann Oncol. doi: 10.1093/annonc/mdq066
- 8.von Wolff M, Zeeb C, Lawrenz B, Germeyer A., Neunhoeffer E, Strowitzki T (2009) Cryopreservation of ovarian tissue and cryopreservation of oocytes can be efficiently combined and performed within 2 weeks before chemotherapy. Hum Reprod 24(1) Abstract Book P-392Google Scholar