Archives of Gynecology and Obstetrics

, Volume 282, Issue 6, pp 717–718 | Cite as

Comments on the letter “Fertility preservation and GnRHa for chemotherapy: debate”

  • Michael von WolffEmail author
  • Juliane Raddatz
  • Michael K. Bohlmann
  • Petra Stute
  • Thomas Strowitzki
  • Markus Nitzschke
Letter to the Editor

Thank you very much for the critical comments. Any critical comment on the use of GnRH analogs (GnRHa) to protect fertility during chemotherapy is of great value in further discussions of the controversial data and the controversial attitudes of endocrinologists and ocologists.

We fully agree with the authors of the letter that several studies support the efficacy of GnRHa to protect the ovaries, which we have also demonstrated in a review summarizing nine studies on the use of GnRHa [1]. We also agree with the authors that the efficacy of other fertility preserving techniques such as cryopreservation and transplantation of ovarian tissue need further evaluation and that their safety has still not absolutely been proven, as stated in our recent review about cryopreservation of ovarian tissue [2]. Finally, we are fully aware that GnRHa provide several additional advantages during chemotherapy such as reducing the risk of thrombocytopenia-associated menorrhagia.

However, we do not agree...


Breast Cancer Patient Ovarian Tissue Ovarian Stimulation Fertility Preservation GnRH Analog 
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Conflict of interest statement



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    von Wolff M, Zeeb C, Lawrenz B, Germeyer A., Neunhoeffer E, Strowitzki T (2009) Cryopreservation of ovarian tissue and cryopreservation of oocytes can be efficiently combined and performed within 2 weeks before chemotherapy. Hum Reprod 24(1) Abstract Book P-392Google Scholar
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    von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, Strowitzki T (2009) Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril 92:1360–1365CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Michael von Wolff
    • 1
    Email author
  • Juliane Raddatz
    • 2
  • Michael K. Bohlmann
    • 3
  • Petra Stute
    • 1
  • Thomas Strowitzki
    • 2
  • Markus Nitzschke
    • 1
  1. 1.Department of Gynecological Endocrinology and Reproductive MedicineWoman’s University Hospital of BernBernSwitzerland
  2. 2.Department of Gynecological Endocrinology and Reproductive MedicineWoman’s University Hospital of HeidelbergHeidelbergGermany
  3. 3.Department of Obstetrics and GynecologyUniversity Hospital of Schleswig–HolsteinLuebeckGermany

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