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Archives of Gynecology and Obstetrics

, Volume 283, Issue 4, pp 755–759 | Cite as

A significant linear association exists between advanced maternal age and adverse perinatal outcome

  • Shimrit Salem Yaniv
  • Amalia Levy
  • Arnon Wiznitzer
  • Gershon Holcberg
  • Moshe Mazor
  • Eyal SheinerEmail author
Materno-Fetal Medicine

Abstract

Objective

The present study was aimed to investigate perinatal outcome of elderly nulliparous patients.

Study design

A retrospective study was performed comparing pregnancy outcomes of nulliparous patients at three age groups: less than 35 years (reference group), 35–40 years, and above 40 years. The linear-by-linear association test was used to examine linear association between advanced maternal age and adverse pregnancy outcomes. A multiple logistic regression model was used to control for confounders.

Results

Out of 45,033 nulliparous women with singleton gestations, 1,036 were of women over the age of 35, and 188 over 40. A significant linear association was documented between advanced maternal age and adverse outcomes, such as intra uterine growth restriction, low birth weight, congenital malformations, and perinatal mortality. Using a multiple logistic regression model, controlling for gestational age, IUGR and malformations, advanced maternal age was not found to be an independent risk factor for perinatal mortality (adjusted odds ratio = 1.04, 95% confidence interval 0.7–1.4).

Conclusion

A significant linear association exists between advanced maternal age and adverse maternal and perinatal outcomes. Nevertheless, in our population, advanced maternal age is not an independent risk factor for perinatal mortality.

Keywords

Advanced maternal age Perinatal mortality Intra uterine growth restriction Low birth weight 

Notes

Conflict of interest statement

None.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Shimrit Salem Yaniv
    • 1
  • Amalia Levy
    • 2
  • Arnon Wiznitzer
    • 1
  • Gershon Holcberg
    • 1
  • Moshe Mazor
    • 1
  • Eyal Sheiner
    • 1
    Email author
  1. 1.Department of Obstetrics and GynecologySoroka University Medical CenterBeershebaIsrael
  2. 2.Epidemiology and Health Evaluation Department, Faculty of Health SciencesBen-Gurion University of the NegevBeershebaIsrael

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