Archives of Gynecology and Obstetrics

, Volume 282, Issue 1, pp 43–47

Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis

General Gynecology

DOI: 10.1007/s00404-009-1241-7

Cite this article as:
Novakov Mikic, A. & Budakov, D. Arch Gynecol Obstet (2010) 282: 43. doi:10.1007/s00404-009-1241-7



Bacterial vaginosis (BV) is characterized by a mixed flora of pathogenic anaerobic bacteria and associated with risks of pathologic conditions. In the present study, therapy with a local antiseptic spray (octenidine hydrochloride/phenoxyethanol, OHP) for 7 or 14 days is compared against the standard local therapy of BV (metronidazole) in a Serbian patient population.


As much as 450 women were treated in groups with either 7 days metronidazole vaginal tablets, 7 days OHP, or 14 days OHP. Control smears were taken after each treatment period.


In total, 63.2% of the women were without indications of BV after therapy (metronidazole: 61.0%, OHP 7 days: 57.6%, and OHP 14 days: 71.0%). Significantly fewer women were affected from infections after treatment with 14 days OHP compared to OHP for 7 days.


Octenidine hydrochloride/phenoxyethanol spray was as effective as the standard therapy with metronidazole. Patients stated that OHP was more comfortable, easier to apply, and side effects were lesser.


Bacterial vaginosis Metronidazole Octenidine hydrochloride, Phenoxyethanol 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Obstetrics and GynaecologyClinical Centre of VojvodinaNovi SadSerbia

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