Abstract
Background
Aggressive angiomyxoma is an uncommon soft tissue tumor which preferentially involves pelvic and vulvoperineal regions of young adult females. The typical characteristics include gelatinous appearance and locally infiltrative nature without evidence of nuclear atypia or mitosis. Treatment involves surgery, but local recurrence is high in spite of apparently complete surgical resection.
Case
A 28-year-old woman who had had a history of surgically excised aggressive angiomyxoma of vulva presented with a complaint of vulvar mass. The mass was removed and histopathologic examination revealed an aggressive angiomyxoma without necrosis, atypia, and mitosis.
Conclusion
Aggressive angiomyxoma should be kept in mind when an asymptomatic and slow-growing vulvar mass is detected in young females. The surgery should aim wide local excision and long-term follow-up is necessary due to high rate of local recurrence.
References
Awad Z, O’Dowd G, Sproule J, Ryan T, O’Reilly T (1999) Aggressive angiomyxoma. Ir Med J 92:343
Chan YM, Hon E, Ngai SW, Ng TY, Wong LC (2000) Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand 79:216–220. doi:10.1034/j.1600-0412.2000.079003216.x
Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM (1996) Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer 78:79–90. doi:10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR13>3.0.CO;2-4
Gungor T, Zengeroglu S, Kaleli A, Kuzey Mocan G (2004) Aggressive angiomyxoma of the vulva and vagina. A common problem: misdiagnosis. Eur J Obstet Gynecol Reprod Biol 112:114–116. doi:10.1016/S0301-2115(03)00270-7
Jeyadevan NN, Sohaib SA, Thomas JM, Jeyarajah A, Shepherd JH, Fisher C (2003) Imaging features of aggressive angiomyxoma. Clin Radiol 58:157–162. doi:10.1053/crad.2002.1127
Magtibay PM, Salmon Z, Keeney GL, Podratz KC (2006) Aggressive angiomyxoma of the female pelvis and perineum: a case series. Int J Gynecol Cancer 16:396–401. doi:10.1111/j.1525-1438.2006.00225.x
Piura B, Shaco-Levy R (2005) Pedunculated aggressive angiomyxoma arising from the vaginal suburethral area: case report and review of literature. Eur J Gynaecol Oncol 26:568–571
Siassi RM, Papadopoulos T, Matzel KE (1999) Metastasizing aggressive angiomyxoma. N Engl J Med 341:1772. doi:10.1056/NEJM199912023412315
Smith HO, Worrell RV, Smith AY, Dorin MH, Rosenberg RD, Bartow SA (1991) Aggressive angiomyxoma of the female pelvis and perineum: review of the literature. Gynecol Oncol 42:79–85. doi:10.1016/0090-8258(91)90235-W
Steeper TA, Rosai J (1983) Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol 7:463–475. doi:10.1097/00000478-198307000-00009
Conflict of interest statement
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Salman, M.C., Kuzey, G.M., Dogan, N.U. et al. Aggressive angiomyxoma of vulva recurring 8 years after initial diagnosis. Arch Gynecol Obstet 280, 485–487 (2009). https://doi.org/10.1007/s00404-009-0934-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-009-0934-2