Unusually large extraintestinal GIST presenting as an abdomino-pelvic tumor
- First Online:
- 173 Downloads
Gastrointestinal stromal tumor (GIST) is a rare visceral tumor that may mimic ovarian tumor.
A 56-year-old woman presented with a large abdomino-pelvic mass and moderately elevated CA-125. A large tumor occupying the whole abdominal cavity and pelvis was noted on laparotomy. In addition, multiple tumor nodules were seen from the ligament of Treitz to the terminal ileum involving only the surface intestine. The ovaries appeared normal. The tumor demonstrated spindle and epithelioid components and was found to be morphologically and immunohistochemically consistent with GIST.
Gynecologists need to be cognizant of extra-ovarian pathology in the atypical presentation of a pelvic mass. Correct diagnosis is essential for proper management since GISTs specifically respond to the c-kit selective tyrosine kinase inhibitor, Imatinib mesylate.
KeywordsGIST Gastrointestinal stromal tumor Extraintestinal GIST
- 2.Rosai J (2004) Surgical pathology, 9th edn. Stromal tumors (GIST s and related lesions), pp 674–680Google Scholar
- 3.Ronnett BM, Kurman RJ, Shmookler BM, Sugarbaker PH, Young RH (1997) The morphologic spectrum of ovarian metastases of appendiceal adenocarcinomas: a clinicopathologic and immunohistochemical analysis of tumors often misinterpreted as primary ovarian tumors or metastatic tumors from other gastrointestinal sites. Am J Surg Pathol 21:1144–1155PubMedCrossRefGoogle Scholar
- 10.Blackstein ME, Rankin B, Fletcher C, Heinrich M, Benjamin R, Mehren MV, Blanke C, Fletcher JA, Borden E, Demetri G (2005) Clinical benefit of Imatinib in patients with metastatic GIST negative for the expression of CD117 in the S0033 trial. ASCO, J Clin Oncol, 9010Google Scholar