Archives of Gynecology and Obstetrics

, Volume 277, Issue 1, pp 67–69 | Cite as

Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine

  • V. Schwarzer
  • A. Heep
  • U. Gembruch
  • A. RohdeEmail author
Case Report


Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil©). Nausea and vomiting resolved within 5 days. After discharge from the hospital in 28 weeks of gestation and discontinuation of the medication on her own initiative a relapse occurred, once again with good response to mirtazapine. The drug was continued until birth. At 34 + 0 weeks a cesarian section was performed due to fetal growth restriction and deteriorating preecplampsia. During the second and fourth day postnatal age the child temporarily developed hyperarousal which could be explained by mirtazapine withdrawal.


Antidepressant Diabetes mellitus Hyperemesis gravidarum Mirtazapine Mirtazapine withdrawal 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of Obstetrics and Prenatal MedicineUniversity Clinics of BonnBonnGermany
  2. 2.Department of NeonatologyUniversity Clinics of BonnBonnGermany
  3. 3.Department of Psychosomatics in GynecologyUniversity Clinics of BonnBonnGermany

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