Archives of Gynecology and Obstetrics

, Volume 275, Issue 5, pp 373–379

The efficacy of 2002 CDC guidelines in preventing perinatal group B Streptococcal vertical transmission: a prospective study

  • Davide Lijoi
  • Elisa Di Capua
  • Simone Ferrero
  • Emanuela Mistrangelo
  • Alessandro Giannattasio
  • Sandra Morano
  • Nicola Ragni
Original Article

Abstract

Objectives

The aim of the current study is to evaluate the differences in the rate of perinatal group B streptococcal vertical transmission between women who correctly underwent the CDC 2002 guidelines and women who did not.

Methods

Two study groups: women who correctly underwent the CDC 2002 guidelines (study group 1) and women who did not (study group 2). Intrapartum chemoprophylaxis (IC) was administered to all pregnant women identified as GBS carrier. All newborns received, in the first hour of life, a culture based screening for GBS colonization.

Results

One thousand six hundred and sixty nine women were enrolled in the study. The 2002 CDC guidelines were correctly applied in 1273 (76.3%) subjects. There was no early-onset GBS disease. No statistically significant difference in the total number of colonized newborns between study group 1 (4.1%) and study group 2 (3.3%) was found. When the analysis was limited to women with positive GBS screening, a significant difference (P < 0.001) was observed in the number of colonized newborns between mothers who received IC during at least 4 h (group 1; 3.7%) and those who received an IC during less than 4 h (group 1; 12.3%).

Conclusion

The accurate application of the 2002 CDC guidelines is strongly supported but, to furthermore reduce the risk for GBS colonization and sepsis in the newborns, it appears desirable to identify additional and new prevention strategies.

Keywords

2002 CDC guidelines GBS culture based screening GBS vertical transmission Group B Streptococcus (GBS) Intrapartum chemoprophylaxis 

Abbreviations

AAP

American Academy of Pediatrics

ACOG

American College of Obstetricians and Gynecologists

CDC

Centers for Disease Control and Prevention

EOGBS

Early-onset group B Streptococcus disease

g

Gram

GBS

Group B Streptococcus

IC

Intrapartum chemoprophylaxis

mg

Milligram

ml

Milliliter

n

Number

μg

Microgram

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Davide Lijoi
    • 1
  • Elisa Di Capua
    • 1
  • Simone Ferrero
    • 1
  • Emanuela Mistrangelo
    • 1
  • Alessandro Giannattasio
    • 2
  • Sandra Morano
    • 1
  • Nicola Ragni
    • 1
  1. 1.Department of Obstetrics and Gynaecology, San Martino HospitalUniversity of GenoaGenoaItaly
  2. 2.Department of PaediatricsGenoa UniversityGenoaItaly

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