Archives of Gynecology and Obstetrics

, Volume 274, Issue 6, pp 367–371

Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma

  • D. Herr
  • H. Bettendorf
  • D. Denschlag
  • C. Keck
  • D. Pietrowski
Original Article



To investigate the association between the occurrence of uterine leiomyoma and two SNPs of the CYP 2A13 and CYP 1A1 genes.

Method of study

Prospective case control study with 132 women with clinically and surgically diagnosed uterine leiomyoma and 260 controls. Genotyping was performed by polymerase chain reaction (PCR) based amplification of CYP 2A13 and CYP 1A1 genes, and restriction fragment length polymorphism (RFLP) analysis.


Comparing women with uterine leiomyoma and controls, we demonstrate statistical significant differences of allele frequency and genotype distribution for the CYP 1A1 polymorphism (P = 0.025 and P = 0.046, respectively). Furthermore, for the CYP 2A13 polymorphism we found a significant difference concerning allele frequency (P = 0.033). However, for the genotype distribution, only borderline significance was observed (P = 0.064).


The CYP 2A13 and CYP 1A1 SNPs are associated with uterine leiomyoma in a Caucasian population and may contribute to the understanding of the pathogenic mechanisms of uterine leiomyoma.


CYP 1A1 CYP 2A13 Leiomyoma Polymorphism 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • D. Herr
    • 1
    • 2
    • 3
  • H. Bettendorf
    • 2
  • D. Denschlag
    • 2
  • C. Keck
    • 2
  • D. Pietrowski
    • 2
  1. 1.Department of Obstetrics and GynecologyUlm University Medical CenterUlmGermany
  2. 2.Department of Obstetrics and GynecologyFreiburg University Medical CenterFreiburgGermany
  3. 3.Universitäts-Frauenklinik UlmUlmGermany

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