Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma
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To investigate the association between the occurrence of uterine leiomyoma and two SNPs of the CYP 2A13 and CYP 1A1 genes.
Method of study
Prospective case control study with 132 women with clinically and surgically diagnosed uterine leiomyoma and 260 controls. Genotyping was performed by polymerase chain reaction (PCR) based amplification of CYP 2A13 and CYP 1A1 genes, and restriction fragment length polymorphism (RFLP) analysis.
Comparing women with uterine leiomyoma and controls, we demonstrate statistical significant differences of allele frequency and genotype distribution for the CYP 1A1 polymorphism (P = 0.025 and P = 0.046, respectively). Furthermore, for the CYP 2A13 polymorphism we found a significant difference concerning allele frequency (P = 0.033). However, for the genotype distribution, only borderline significance was observed (P = 0.064).
The CYP 2A13 and CYP 1A1 SNPs are associated with uterine leiomyoma in a Caucasian population and may contribute to the understanding of the pathogenic mechanisms of uterine leiomyoma.
KeywordsCYP 1A1 CYP 2A13 Leiomyoma Polymorphism
- 4.Wu J, Cheng Y (1995) [Research on the relationship between estrogen receptor, progesterone receptor, cell proliferation associated antigen in uterine leiomyoma and nuclear body density of myoma, serum reproductive hormone concentrations]. Zhonghua Fu Chan Ke Za Zhi 30(10):603–607PubMedGoogle Scholar
- 11.Somner J, McLellan S, Cheung J, Mak YT, Frost ML, Knapp KM et al (2004) Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women. J Clin Endocrinol Metab 89(1):344–351PubMedCrossRefGoogle Scholar
- 24.Amant F, Dorfling CM, de Brabanter J, Vandewalle J, Vergote I, Lindeque BG et al (2004) A possible role of the cytochrome P450c17alpha gene (CYP17) polymorphism in the pathobiology of uterine leiomyomas from black South African women: a pilot study. Acta Obstet Gynecol Scand 83(3):234–239PubMedCrossRefGoogle Scholar