Archives of Gynecology and Obstetrics

, Volume 275, Issue 1, pp 5–11

Validation of fetal cerebellar volume by three-dimensional ultrasonography in Brazilian population

  • Edward Araujo Júnior
  • Hélio A. Guimarães Filho
  • Cláudio R. Pires
  • Luciano M. Nardozza
  • Antonio F. Moron
  • Rosiane Mattar
Original Article

Abstract

Background

To validate the prediction equation of the volume of fetal cerebellum by three-dimensional ultrasonography determined for Taiwan’s population in Brazilian population.

Methods

A longitudinal prospective study was performed with 52 normal pregnant women between 20 and 32 weeks. The measurement of fetal cerebellar volume was done by virtual organ computer-aided analysis (VOCALTM) method, with a rotation angle of 30°. To establish the correlation of fetal cerebellar volume with gestational age, a polynomial regression analysis was performed, with cerebellar volume as dependent variable and gestational age as independent variable. To compare the prediction equation of the volume of fetal cerebellum in Taiwan’s population and the equation established in this study, with the values obtained from Brazilian population (referential), we used the intraclass correlation coefficient, with the averages compared by paired Student’s t test.

Results

The volume of fetal cerebellum was highly correlated with gestational age, and the best prediction equation obtained was of the second degree. The equation established in this study predicted cerebellar volumes more accurately than the equation established for Taiwan’s population, since the average values of fetal cerebellar volume were more similar to the average values of reference.

Conclusions

The equation established for Taiwan’s population presented less accuracy in Brazilian population, possibly due to the strong ethnical differences between both populations.

Keywords

Cerebellum volume Fetus Three-dimensional imaging 

References

  1. 1.
    Goldstein I, Reece EA, Pilu G, Bovicelli L, Hobbins JC (1987) Cerebellar measurements with ultrasonography in the evaluation of growth and development. Am J Obstet Gynecol 156(5):1065–1069PubMedGoogle Scholar
  2. 2.
    Babcook CJ, Chong BW, Salamat MS, Ellis WG, Goldstein RB (1996) Sonographic anatomy of the developing cerebellum: normal embryology can resemble pathology. AJR Am J Roentgenol 166:427–433PubMedGoogle Scholar
  3. 3.
    Reece EA, Goldstein I, Pilu G, Hobbins JC (1987) Fetal cerebellar growth unaffected by intrauterine growth retardation: a new parameter for prenatal diagnosis. Am J Obstet Gynecol 157(3):632–638PubMedGoogle Scholar
  4. 4.
    Lee W, Barton S, Comstock CH, Bajorek S, Batton D, Kirk JS (1991) Transverse cerebellar diameter: a useful predictor of gestational age for fetuses with asymmetric growth retardation. Am J Obstet Gynecol 165:1044–1050PubMedGoogle Scholar
  5. 5.
    Vinkesteijn ASM, Mulder PGH, Wladimiroff JW (2000) Fetal transverse cerebellar diameter measurements in normal and reduced fetal growth. Ultrasound Obstet Gynecol 15:47–51PubMedCrossRefGoogle Scholar
  6. 6.
    Rotmensch S, Goldstein I, Liberati M, Shalev J, Ben-Rafael Z, Cople J (1997) Fetal transcerebellar diameter in Down syndrome. Obstet Gynecol 89(4):534–537PubMedCrossRefGoogle Scholar
  7. 7.
    Hata T, Yanagihara T, Matsumoto M, Hanaoka U, Ueta M, Tanaka Y et al (2000) Three-dimensional sonographic features of central nervous system anomaly. Am Obstet Gynecol Scand 79:635–639CrossRefGoogle Scholar
  8. 8.
    Blaas HG, Eik-Nes SH, Kiserud T, Berg S, Angelsen B, Olstad B (1995) Three-dimensional imaging of the brain cavities in human embryos. Ultrasound Obstet Gynecol 5(4):228–232PubMedCrossRefGoogle Scholar
  9. 9.
    Chang CH, Chang FM, Yu CH, Ko HC, Chen HY (2000b) Assessment of fetal cerebellar volume using three-dimensional ultrasound. Ultrasound Med Biol 26(6):981–988CrossRefGoogle Scholar
  10. 10.
    Lee A, Kratochwil A, Stümpflen I, Deutinger J, Bernaschiek G (1996) Fetal lung volume determination by three-dimensional ultrasonography. Am J Obstet Gynecol 175:588–592PubMedCrossRefGoogle Scholar
  11. 11.
    Chang FM, Hsu KF, Ko HC, Yao BL, Chang CH, Yu CH et al (1997a) Three-dimensional ultrasound assessment of fetal liver volume in normal pregnancy: a comparison of reproducibility with two-dimensional ultrasound and a search for volume constant. Ultrasound Med Biol 23(3):381–389CrossRefGoogle Scholar
  12. 12.
    Chang FM, Hsu KF, Ko HC, Yao BL, Chang CH, Yu CH (1997b) Fetal heart volume assessment by three-dimensional ultrasound. Ultrasound Obstet Gynecol 9:42–48CrossRefGoogle Scholar
  13. 13.
    Laudy JAM, Janssen MMM, Struyk PC, Stijnen T, Wallenburg HCS, Wladimiroff W (1998) Fetal liver volume measurement by three-dimensional ultrasonography: a preliminary study. Ultrasound Obstet Gynecol 12:93–96PubMedCrossRefGoogle Scholar
  14. 14.
    Pöhls UG, Rempen A (1998) Fetal lung volumetry by three-dimensional ultrasound. Ultrasound Obstet Gynecol 11:6–12PubMedCrossRefGoogle Scholar
  15. 15.
    Bahmaie A, Hughes SW, Clark T, Milner A, Saunders J, Tilling K et al (2000) Serial fetal lung volume measurement using three-dimensional ultrasound. Ultrasound Obstet Gynecol 16:154–158PubMedCrossRefGoogle Scholar
  16. 16.
    Hsieh YY, Chang CC, Lee CC, Tsai HR (2000) Fetal renal volume assessment by three-dimensional ultrasonography. Am J Obstet Gynecol 182(2):377–379PubMedCrossRefGoogle Scholar
  17. 17.
    Raine-Fenning NJ, Clewes JS, Kendall NR, Bunkheila AK, Campbell BK, Johnson IR (2003) The interobserver reliability and validity of volume calculation from three-dimensional ultrasound datasets in the in vitro setting. Ultrasound Obstet Gynecol 21(3):283–291PubMedCrossRefGoogle Scholar
  18. 18.
    Ruano R, Martinovic J, Dommergues M, Aubry MC, Dumez Y, Benachi A (2005) Accuracy of fetal lung volume assessed by three-dimensional sonography. Ultrasound Obstet Gynecol 26:725–730PubMedCrossRefGoogle Scholar
  19. 19.
    Jacquemyn Y, Sys SU, Verdonk P (2000) Fetal transverse cerebellar diameter in different ethnic groups. J Perinat Med 28:14–19PubMedCrossRefGoogle Scholar
  20. 20.
    McLeary RD, Kuhns LR, Barr M Jr (1984) Ultrasonography of the fetal cerebellum. Radiology 151(2):439–442PubMedGoogle Scholar
  21. 21.
    Chang CH, Chang FM, Yu CH, Ko HC, Chen HY (2000a) Three-dimensional ultrasound in the assessment of fetal cerebellar transverse and antero-posterior diameters. Ultrasound Med Biol 26(2):175–182CrossRefGoogle Scholar
  22. 22.
    Riccabona M, Nelson TR, Pretorius DH (1996) Three-dimensional ultrasound: accuracy of distance and volume measurements. Ultrasound Obstet Gynecol 7:429–434PubMedCrossRefGoogle Scholar
  23. 23.
    Ruano R, Joubin L, Sonigo P, Benachi A, Aubry MC, Thalabard JC et al (2004) Fetal lung volume estimated by 3-dimensional ultrasonography and magnetic resonance imaging in cases with isolated congenital diaphragmatic hernia. J Ultrasound Med 23:353–358PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Edward Araujo Júnior
    • 1
  • Hélio A. Guimarães Filho
    • 1
  • Cláudio R. Pires
    • 1
  • Luciano M. Nardozza
    • 1
  • Antonio F. Moron
    • 1
  • Rosiane Mattar
    • 1
  1. 1.Department of ObstetricsSao Paulo’s Federal University (Unifesp/EPM)São PauloBrazil

Personalised recommendations