Archives of Gynecology and Obstetrics

, Volume 275, Issue 2, pp 145–148 | Cite as

Granulosa cell tumor arising in the wall of müllerian cyst of the broad ligament: report of a case and immunohistochemical study

  • Yu SakaiEmail author
Case Report



A unique case of granulosa cell tumor arising in a müllerian cyst of the broad ligament in a 57-year-old woman is presented. The surgically resected unilocular cyst, measuring 9.5 × 9.5 × 6.5 cm3, situated within the right broad ligament. The inner surface of the cyst was lined by a single layer of ciliated columnar cells. Solid cell sheath of the spindled cells were demonstrated in this cystic wall. Immunohistochemically, these spindled cells were diffusely positive for cytokeratin 7, AE1/AE3, vimentin, smooth muscle actin, calretinin and weakly positive for inhibin, but negative for cytokeratin 20, epithelial membrane antigen and CD10.


Immunohistochemical findings suggested solid cell sheath surrounding the cyst was granulosa cell tumor. Granulosa cell tumor coexisted with müllerian cyst in the current case was recognized a unique histological feature.


Granulosa cell tumor Broad ligament Müllerian cyst Wolffian adnexal tumor Immunohistochemistry 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of PathologyJapan Self Defense Forces Sapporo General HospitalSapporo, HokkaidoJapan

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